{"id":"W4289517508","doi":"10.3389/fncel.2022.972029","title":"Suppression of the necroptotic cell death pathways improves survival in Smn2B/− mice","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Ottawa Hospital; University of Ottawa","funders":"Muscular Dystrophy Canada; Canadian Institutes of Health Research; University of Ottawa; Muscular Dystrophy Association","keywords":"Necroptosis; Programmed cell death; Neuroscience; Cell survival; Biology; Cancer research; Cell biology; Medicine; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003112698,0.0009811284,0.0006803672,0.0008541535,0.0002993026,0.0004223283,0.0004429956,0.0009168591,0.001888599],"category_scores_gemma":[0.0001704045,0.0003558935,0.0005580675,0.0002281873,0.0004884779,0.0004686688,0.0002870762,0.001584735,0.000694501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003513954,"about_ca_system_score_gemma":0.0002618131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005820392,"about_ca_topic_score_gemma":0.001018883,"domain_scores_codex":[0.9996707,0.00004930427,0.00006819437,0.00008533283,0.00007720348,0.00004924097],"domain_scores_gemma":[0.9995641,0.00002966253,0.0001455906,0.00002336914,0.00002988759,0.0002073354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004446037,0.000110958,0.0001400525,0.00004939862,0.000008783421,0.00005899275,0.00002163188,0.00007694854,0.9981824,0.00004232826,0.00005199473,0.0008119228],"study_design_scores_gemma":[0.0002751175,0.004510193,0.0081179,0.00005963056,0.00007090441,0.0008033738,0.00012993,0.001598592,0.9808682,0.0001418894,0.003397156,0.00002720589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938427,0.001545683,0.001991839,0.0002200499,0.00008894281,0.00006581439,0.001248191,0.0001955972,0.000801164],"genre_scores_gemma":[0.9808693,0.002539439,0.006081773,0.000248639,0.00004556939,0.0002769038,0.002163785,0.0001566979,0.007617781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001888599,"threshold_uncertainty_score":0.006318033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488320015488048,"score_gpt":0.2023853188667682,"score_spread":0.1875021187118877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}