{"id":"W4289519023","doi":"10.1101/2022.07.29.502090","title":"Obesity promotes breast epithelium DNA damage in BRCA mutation carriers","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Risks and Factors","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; Weill Cornell Medical College; National Breast Cancer Foundation","keywords":"Breast cancer; Internal medicine; Population; Endocrinology; Cancer research; Biology; Mutation; Adipose tissue; BRCA mutation; DNA damage; Cancer; Medicine; Genetics; Gene; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006722517,0.0005665131,0.0008287391,0.0005216722,0.0001679883,0.0001085246,0.000359967,0.0004381155,0.0006302895],"category_scores_gemma":[0.0001616215,0.0006175028,0.0002301556,0.0007476726,0.0001340891,0.0001426086,0.0004826993,0.001497935,0.00002868469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00128917,"about_ca_system_score_gemma":0.001403483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001520468,"about_ca_topic_score_gemma":0.00007586793,"domain_scores_codex":[0.9968841,0.0001692055,0.000620871,0.001103937,0.0006168307,0.0006050422],"domain_scores_gemma":[0.9976626,0.00004818798,0.0003888773,0.001247748,0.0002748818,0.0003777033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003948225,0.0009287144,0.6698418,0.001978114,0.0004146326,0.00147593,0.0002435621,0.0001988413,0.3236696,0.0002652747,0.0005627793,0.00002593798],"study_design_scores_gemma":[0.001294386,0.0001151643,0.9609988,0.0004539258,0.0001996188,1.998672e-7,0.00003162682,0.0003136763,0.03282847,0.000002780131,0.003093691,0.0006676373],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994993,0.0005140351,0.00009424835,0.0005065417,0.001173274,0.001432005,0.0009331728,0.0003226616,0.00003101644],"genre_scores_gemma":[0.9982202,0.0001319783,0.0005424566,0.0002085663,0.0004115029,0.0003051881,0.000004361584,0.0001536146,0.0000221512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.291157,"threshold_uncertainty_score":0.9996276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191702426613203,"score_gpt":0.238892113746943,"score_spread":0.226975089480811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}