{"id":"W4289519023","doi":"10.1101/2022.07.29.502090","title":"Obesity promotes breast epithelium DNA damage in BRCA mutation carriers","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Risks and Factors","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; Weill Cornell Medical College; National Breast Cancer Foundation","keywords":"Breast cancer; Internal medicine; Population; Endocrinology; Cancer research; Biology; Mutation; Adipose tissue; BRCA mutation; DNA damage; Cancer; Medicine; Genetics; Gene; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003197652,0.0001854454,0.000216263,0.000528221,0.0002428785,0.0003892135,0.0001290838,0.0004553719,0.01374818],"category_scores_gemma":[0.0005740941,0.00011841,0.0001309666,0.0002020556,0.0001414352,0.0001153656,0.0001869679,0.0003312746,0.002863299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001475937,"about_ca_system_score_gemma":0.0001671007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004928025,"about_ca_topic_score_gemma":0.0006233271,"domain_scores_codex":[0.999894,0.0000169966,0.000005044733,0.00002019466,0.00005415826,0.00000965789],"domain_scores_gemma":[0.999686,0.0001118855,0.0000627931,0.00001699313,0.00005154621,0.00007068735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002070883,0.0003077189,0.0496934,0.001180753,0.0001214588,0.002992319,0.0003340617,0.0003522239,0.6053576,0.002575622,0.2706134,0.06440064],"study_design_scores_gemma":[0.0002067811,0.001059308,0.4487233,0.0002447626,0.0001967064,0.01350261,0.0004359492,0.002026687,0.2507436,0.004212688,0.2785774,0.00007013955],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8876425,0.01281092,0.007479979,0.03965212,0.01130799,0.0001295522,0.01519797,0.001717466,0.02406158],"genre_scores_gemma":[0.8562273,0.008307969,0.004866071,0.005560207,0.005605989,0.00008971292,0.008090319,0.0004877767,0.1107646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01374818,"threshold_uncertainty_score":0.0459922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191702426613203,"score_gpt":0.238892113746943,"score_spread":0.226975089480811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}