{"id":"W4289523904","doi":"10.3389/fimmu.2022.943481","title":"CpG content in the Zika virus genome affects infection phenotypes in the adult brain and fetal lymph nodes","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Innovation Saskatchewan","keywords":"Zika virus; Biology; CpG site; Virus; Virology; Phenotype; Placenta; Immune system; Microcephaly; Genome; Viral replication; Attenuated vaccine; Immunology; Fetus; Genetics; Gene; DNA methylation; Pregnancy; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008214446,0.0002160205,0.000101363,0.0001552738,0.00007530701,0.0002203947,0.0001357752,0.0002427487,0.001088163],"category_scores_gemma":[0.0001453544,0.0001314725,0.0001646823,0.00006076551,0.0002242346,0.0001732645,0.0001535069,0.0007714127,0.0001737791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000219015,"about_ca_system_score_gemma":0.0001326669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001209528,"about_ca_topic_score_gemma":0.001649431,"domain_scores_codex":[0.9998926,0.00001052962,0.000008319402,0.00003508353,0.00001749696,0.00003593771],"domain_scores_gemma":[0.9998761,0.00002352718,0.00003925209,0.000009959184,0.00001359327,0.00003751005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001041762,0.0000142955,0.0003400141,0.00001539594,0.000003282253,0.00002298104,0.00001695657,0.00002426488,0.9988311,0.00002633124,0.00001291152,0.0005883477],"study_design_scores_gemma":[0.00001735699,0.001105188,0.03675413,0.00001517412,0.00003680423,0.0003221513,0.0001361995,0.0008157043,0.9593659,0.00008104265,0.001338636,0.00001165812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975812,0.0004336718,0.0009164394,0.0000385311,0.00001567957,0.00001604504,0.0004511088,0.00002687407,0.0005202483],"genre_scores_gemma":[0.9960009,0.000534336,0.001157532,0.0000631123,0.0000037559,0.00004107986,0.0006603479,0.00002272834,0.001516148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001209528,"threshold_uncertainty_score":0.003640294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009086140687529474,"score_gpt":0.2252114082171667,"score_spread":0.2161252675296372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}