{"id":"W4289524108","doi":"10.3390/cancers14153759","title":"Knockdown of CKAP2 Inhibits Proliferation, Migration, and Aggregate Formation in Aggressive Breast Cancer","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; PROTEO","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fondation du cancer du sein du Québec","keywords":"Mitosis; Gene knockdown; SKBR3; Cancer research; Biology; Carcinogenesis; Breast cancer; Estrogen receptor; Cell growth; Cancer; Transcriptome; Aneuploidy; Cell cycle; Gene expression; Gene; Cell biology; Chromosome; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001215043,0.0003001358,0.0003773448,0.0003232426,0.0002379488,0.0003557537,0.0001409894,0.0001863688,0.0008836317],"category_scores_gemma":[0.00009938749,0.0001375958,0.0002366154,0.0003482168,0.0001176135,0.0001205018,0.0001772077,0.0004649233,0.0002850787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002541925,"about_ca_system_score_gemma":0.0002587501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002019944,"about_ca_topic_score_gemma":0.003748386,"domain_scores_codex":[0.99986,0.00001275473,0.00001401448,0.00003283729,0.00005031266,0.00002998141],"domain_scores_gemma":[0.9999425,0.000008161263,0.00001231563,0.000006616376,0.000008700712,0.00002171521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002414863,0.00006354921,0.0006141663,0.0001146572,0.00003328129,0.00005574556,0.00002186142,0.0002749622,0.9945858,0.00005381529,0.0005087528,0.003431872],"study_design_scores_gemma":[0.00008723299,0.0006344967,0.03553997,0.000021238,0.0001234385,0.0005488622,0.00009426901,0.007381692,0.9414954,0.0001186049,0.01393711,0.00001763586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887217,0.003369616,0.002275368,0.0001481096,0.00006713109,0.00005201032,0.003238834,0.0002914373,0.001835743],"genre_scores_gemma":[0.9892518,0.001931107,0.001836705,0.0001125732,0.000009137584,0.000106006,0.004322779,0.00003841091,0.002391455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002019944,"threshold_uncertainty_score":0.00401634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005794571672946674,"score_gpt":0.228512075672899,"score_spread":0.2227175039999523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}