{"id":"W4289524108","doi":"10.3390/cancers14153759","title":"Knockdown of CKAP2 Inhibits Proliferation, Migration, and Aggregate Formation in Aggressive Breast Cancer","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; PROTEO","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fondation du cancer du sein du Québec","keywords":"Mitosis; Gene knockdown; SKBR3; Cancer research; Biology; Carcinogenesis; Breast cancer; Estrogen receptor; Cell growth; Cancer; Transcriptome; Aneuploidy; Cell cycle; Gene expression; Gene; Cell biology; Chromosome; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006561866,0.00007652844,0.00009114179,0.000051952,0.00008021013,0.00001043783,0.00006042153,0.00003293998,0.000052128],"category_scores_gemma":[0.00003256349,0.00008438983,0.00002205765,0.0001126428,0.00004059623,0.000007100922,0.00007305324,0.00005512016,2.339244e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002326601,"about_ca_system_score_gemma":0.0003995381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007165304,"about_ca_topic_score_gemma":0.003031113,"domain_scores_codex":[0.9994379,0.00002574275,0.0001785288,0.0001627333,0.00008413627,0.000110947],"domain_scores_gemma":[0.9995775,0.000006517512,0.0001846594,0.0001071838,0.00008099103,0.00004311257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001124454,0.00009048406,0.09328072,0.0002501167,0.000115889,0.0000141021,0.003538412,0.1484838,0.6786643,0.0008124537,0.03789589,0.03572943],"study_design_scores_gemma":[0.005156221,0.0007810086,0.04092618,0.0002184446,0.00007274656,0.0002331961,0.001765175,0.01023866,0.8598222,0.0006675523,0.07921015,0.0009084966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953183,0.003344379,0.00006142604,0.00045565,0.0001343384,0.00020969,0.0003352565,0.000002898084,0.000138063],"genre_scores_gemma":[0.9964619,0.002637272,0.00003822647,0.000361783,0.00009000703,0.000192493,0.0001344329,0.000009580317,0.00007424802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1811579,"threshold_uncertainty_score":0.3441317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005794571672946674,"score_gpt":0.228512075672899,"score_spread":0.2227175039999523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}