{"id":"W4289526142","doi":"10.1016/j.dld.2022.07.004","title":"Non-medical switch from the originator to biosimilar and between biosimilars of adalimumab in inflammatory bowel disease – a prospective, multicentre study","year":2022,"lang":"en","type":"article","venue":"Digestive and Liver Disease","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Janssen Pharmaceuticals; Takeda Canada; Emberi Eroforrások Minisztériuma; Ferring Pharmaceuticals; Semmelweis Egyetem; Meso Scale Diagnostics; Merck; AbbVie; Gilead Sciences; Pfizer","keywords":"Biosimilar; Medicine; Adalimumab; Inflammatory bowel disease; Intensive care medicine; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002427039,0.001051359,0.00130203,0.0007734129,0.001050136,0.002137781,0.0006761212,0.001929125,0.003217201],"category_scores_gemma":[0.005459443,0.0009371511,0.002353684,0.001270984,0.001408432,0.001692815,0.0008401814,0.002460671,0.000610147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009826476,"about_ca_system_score_gemma":0.0007877793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001665543,"about_ca_topic_score_gemma":0.00138906,"domain_scores_codex":[0.996981,0.001057174,0.0002573336,0.0009537953,0.0003372103,0.0004135442],"domain_scores_gemma":[0.9947132,0.001575166,0.001811607,0.0006683645,0.0004037921,0.000827803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2688195,0.009760988,0.6982947,0.0005135369,0.003952882,0.0008608417,0.001284314,0.0002299458,0.003383823,0.0002374643,0.0004451991,0.01221685],"study_design_scores_gemma":[0.01248134,0.04293275,0.9377844,0.00009008989,0.002340043,0.000924335,0.0008550666,0.0004683353,0.0005731672,0.0002280569,0.001222416,0.00009992471],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988878,0.0006038653,0.00005985155,0.00001921667,0.00002337387,0.00005211998,0.00009892671,0.000002405617,0.0002524662],"genre_scores_gemma":[0.9988886,0.0002301244,0.00007971271,0.00009795149,0.00005886252,0.00004358413,0.0003155975,0.000004267709,0.0002813476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003217201,"threshold_uncertainty_score":0.01283556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01063467291351041,"score_gpt":0.2642036419642729,"score_spread":0.2535689690507625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}