{"id":"W4289537262","doi":"10.2139/ssrn.4173050","title":"Durability of ChAdOx1 nCoV-19 (AZD1222) Vaccine and Hybrid Humoral Immunity Against Variants Including Omicron BA.1 and BA.4 Six Months after Vaccination: A Randomised, Phase 1b/2a Trial","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Immunogenicity; Antibody; Vaccination; Placebo; Medicine; Immunology; Serology; Internal medicine; Virology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001618405,0.001395516,0.002301093,0.0003260507,0.0004098385,0.00101669,0.0008798988,0.00178671,0.006574207],"category_scores_gemma":[0.001055527,0.0004814119,0.001333219,0.0002955347,0.0008964694,0.001110936,0.0003357116,0.002792405,0.001264959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008104325,"about_ca_system_score_gemma":0.0006741121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009584448,"about_ca_topic_score_gemma":0.001689128,"domain_scores_codex":[0.9993674,0.000278507,0.000037603,0.000110641,0.00005392632,0.0001518962],"domain_scores_gemma":[0.9993326,0.0001714143,0.0001358918,0.00005912385,0.00004158573,0.0002593468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9509188,0.007858757,0.0009628951,0.0004362743,0.001156781,0.00004116584,0.00005300595,0.0004265043,0.005456908,0.0001227472,0.001027551,0.03153866],"study_design_scores_gemma":[0.7565168,0.2350571,0.004672997,0.00005215071,0.0005456403,0.00006768578,0.00003154208,0.0003656713,0.00125622,0.0001939503,0.001219407,0.00002079272],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896311,0.005783448,0.0002945781,0.0004588031,0.0004748545,0.000911759,0.0007313432,0.00008759537,0.001626571],"genre_scores_gemma":[0.9901986,0.002168777,0.0005384923,0.0006797657,0.0003923793,0.0009587704,0.001234606,0.00002075739,0.003807927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006574207,"threshold_uncertainty_score":0.02199292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02177233823682176,"score_gpt":0.330424523818192,"score_spread":0.3086521855813702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}