{"id":"W4289549935","doi":"10.1038/s41375-022-01650-w","title":"Genomic landscape of patients with FLT3-mutated acute myeloid leukemia (AML) treated within the CALGB 10603/RATIFY trial","year":2022,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Bundesministerium für Bildung und Forschung; Universität Ulm; Deutsche Forschungsgemeinschaft","keywords":"Midostaurin; NPM1; Myeloid leukemia; Neuroblastoma RAS viral oncogene homolog; Cancer research; Mutation; CEBPA; Biology; Oncology; Internal medicine; Dasatinib; Leukemia; Fms-Like Tyrosine Kinase 3; Medicine; Genetics; Gene; Imatinib; KRAS","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008400868,0.0005386022,0.000969035,0.0003835578,0.0005940316,0.00005775868,0.0008322458,0.0002242503,0.001239458],"category_scores_gemma":[0.0001627744,0.0003506712,0.0002533678,0.001489758,0.0003762667,0.0001430537,0.0005201537,0.001776427,0.00009856652],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005203151,"about_ca_system_score_gemma":0.004651035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001028824,"about_ca_topic_score_gemma":0.00007526431,"domain_scores_codex":[0.9952882,0.0004929125,0.0009706919,0.0008008188,0.001612713,0.0008346849],"domain_scores_gemma":[0.9971334,0.000301487,0.0005516863,0.001303069,0.0003765999,0.0003336999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5671316,0.001534457,0.2558798,0.0004579761,0.00667373,0.001953477,0.01002035,0.01002988,0.05596887,0.0007373772,0.08157259,0.008039881],"study_design_scores_gemma":[0.5631775,0.02467719,0.3192847,0.0002375399,0.003953433,0.0006499368,0.003901557,0.02713865,0.03220131,0.0002457104,0.02193503,0.00259746],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927465,0.0001342841,0.00003094961,0.0004797157,0.0002981373,0.002973453,0.0003370958,0.0001806935,0.002819137],"genre_scores_gemma":[0.9920167,0.00002518606,0.0003729355,0.0006320896,0.0002542028,0.0004680928,0.001280267,0.0001551963,0.004795361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06340484,"threshold_uncertainty_score":0.9998945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01238620844237441,"score_gpt":0.2550006434376942,"score_spread":0.2426144349953198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}