{"id":"W4289549935","doi":"10.1038/s41375-022-01650-w","title":"Genomic landscape of patients with FLT3-mutated acute myeloid leukemia (AML) treated within the CALGB 10603/RATIFY trial","year":2022,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Bundesministerium für Bildung und Forschung; Universität Ulm; Deutsche Forschungsgemeinschaft","keywords":"Midostaurin; NPM1; Myeloid leukemia; Neuroblastoma RAS viral oncogene homolog; Cancer research; Mutation; CEBPA; Biology; Oncology; Internal medicine; Dasatinib; Leukemia; Fms-Like Tyrosine Kinase 3; Medicine; Genetics; Gene; Imatinib; KRAS","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001160572,0.0001980291,0.001027969,0.0001555697,0.000225776,0.0005094648,0.0002299351,0.0004480106,0.001171977],"category_scores_gemma":[0.001791961,0.0001250377,0.0004262128,0.0003501931,0.000249281,0.0002630629,0.0002542677,0.0004962856,0.000122234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005066128,"about_ca_system_score_gemma":0.000427424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002055215,"about_ca_topic_score_gemma":0.00390081,"domain_scores_codex":[0.998939,0.0006212572,0.00003611518,0.0002033195,0.00009678372,0.0001035486],"domain_scores_gemma":[0.9994134,0.0002292314,0.0001784109,0.00005077353,0.00003039504,0.00009787601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1260374,0.0009353194,0.7323362,0.000215067,0.002815281,0.0004347345,0.0003721099,0.008961704,0.03064487,0.0007119146,0.003423288,0.09311221],"study_design_scores_gemma":[0.005036029,0.009604077,0.9711933,0.00002235332,0.001133334,0.0005481924,0.0001927701,0.006069283,0.001536946,0.0009136201,0.003720671,0.00002937604],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986656,0.0004377203,0.0001374356,0.0001133251,0.00000453324,0.00001540759,0.0003029337,0.000004554652,0.0003185451],"genre_scores_gemma":[0.9983907,0.00009927072,0.0001325473,0.0001552761,0.000009297838,0.00002190021,0.0010496,0.000004321073,0.0001371352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002055215,"threshold_uncertainty_score":0.006137788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01238620844237441,"score_gpt":0.2550006434376942,"score_spread":0.2426144349953198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}