{"id":"W4289593836","doi":"10.1089/nat.2022.0024","title":"Nucleic Acid Aptamers Increase the Anticancer Efficiency and Reduce the Toxicity of Cisplatin-Arabinogalactan Conjugates <i>In Vivo</i>","year":2022,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Aptamer; Cisplatin; In vivo; Pharmacology; Arabinogalactan; Toxicity; Chemistry; Nucleic acid; Ehrlich ascites carcinoma; Bioavailability; Cancer research; Biochemistry; In vitro; Biology; Medicine; Molecular biology; Polysaccharide; Chemotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007026633,0.0004082429,0.0001868688,0.0001594667,0.00007839459,0.0001974383,0.0001480583,0.0002837708,0.00121667],"category_scores_gemma":[0.0001098922,0.000105007,0.0001302629,0.0001119241,0.000130283,0.000177242,0.0001178316,0.0003130116,0.000376432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002172213,"about_ca_system_score_gemma":0.0001340387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002649187,"about_ca_topic_score_gemma":0.000342697,"domain_scores_codex":[0.9999123,0.00001660927,0.000006456721,0.00002254976,0.00002670319,0.00001541582],"domain_scores_gemma":[0.999953,0.000008111657,0.00001596125,0.000004840334,0.000008778709,0.000009180928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003217418,0.00001884673,0.00004111237,0.00001987226,0.000002564644,0.00001657373,0.00000512795,0.00007881911,0.9974899,0.00009968943,0.00004309234,0.002152167],"study_design_scores_gemma":[0.000004020494,0.00008293989,0.0002458586,9.970323e-7,0.000004199561,0.00005413693,0.000001387644,0.0003464607,0.9979906,0.00001661361,0.00125156,0.000001267475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680761,0.003386006,0.02124367,0.0002249913,0.00008812565,0.00009315855,0.000167504,0.0004551055,0.006265279],"genre_scores_gemma":[0.9795941,0.001190071,0.01281351,0.0001181237,0.00001748507,0.00005664893,0.0001684313,0.0000631609,0.00597838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00121667,"threshold_uncertainty_score":0.004070222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01481897651674918,"score_gpt":0.2434518749895445,"score_spread":0.2286328984727953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}