{"id":"W4289593836","doi":"10.1089/nat.2022.0024","title":"Nucleic Acid Aptamers Increase the Anticancer Efficiency and Reduce the Toxicity of Cisplatin-Arabinogalactan Conjugates <i>In Vivo</i>","year":2022,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Aptamer; Cisplatin; In vivo; Pharmacology; Arabinogalactan; Toxicity; Chemistry; Nucleic acid; Ehrlich ascites carcinoma; Bioavailability; Cancer research; Biochemistry; In vitro; Biology; Medicine; Molecular biology; Polysaccharide; Chemotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001642047,0.0002766883,0.0003537031,0.00008109497,0.0006543898,0.0000928048,0.0009183443,0.00006422232,0.0009720853],"category_scores_gemma":[0.00007274042,0.0001864829,0.00009150286,0.0006399198,0.001025606,0.0001799434,0.000429038,0.0003982583,0.0000246209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001404887,"about_ca_system_score_gemma":0.0001677062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001576548,"about_ca_topic_score_gemma":0.00003202127,"domain_scores_codex":[0.9970575,0.0006385422,0.0005560822,0.0004687016,0.0007173347,0.0005618464],"domain_scores_gemma":[0.9982558,0.0004589627,0.0003182654,0.0007928177,0.00008157839,0.00009251965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002966908,0.0002385672,0.002016576,0.00001754937,0.00002160162,0.000008154644,0.002279993,0.0003679404,0.9924305,0.001107861,0.0001610058,0.001053571],"study_design_scores_gemma":[0.001077541,0.0003034132,0.001488734,0.00002266829,0.0001011016,0.0000328938,0.002568317,0.007126587,0.9842983,0.0005313276,0.002157586,0.0002914935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949759,0.001049606,0.00002821886,0.002148874,0.0003598431,0.0005515997,0.0001101896,0.00006653393,0.0007092733],"genre_scores_gemma":[0.9967005,0.0001340652,0.0001355088,0.002839406,0.00005049877,0.00005091037,0.000001535087,0.00004373466,0.00004388359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008132153,"threshold_uncertainty_score":0.9999412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01481897651674918,"score_gpt":0.2434518749895445,"score_spread":0.2286328984727953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}