{"id":"W4289595367","doi":"10.5858/arpa.2021-0632-cp","title":"Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy: Guideline From the College of American Pathologists in Collaboration With the Association for Molecular Pathology and Fight Colorectal Cancer","year":2022,"lang":"en","type":"article","venue":"Archives of Pathology & Laboratory Medicine","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"Smiths Detection (Canada)","funders":"","keywords":"Microsatellite instability; Medicine; Guideline; Colorectal cancer; Context (archaeology); DNA mismatch repair; Cancer; Grading (engineering); Oncology; Immune checkpoint; Internal medicine; Pathology; Immunotherapy; Biology; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001735838,0.0002116619,0.0007080964,0.00009739921,0.0001653054,0.000002491593,0.0001380075,0.00007558898,0.00001009564],"category_scores_gemma":[0.001826796,0.0001296576,0.00005290228,0.0005830022,0.001507816,0.00002509522,0.0001107654,0.0002830932,2.079697e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001251225,"about_ca_system_score_gemma":0.0004683615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002348067,"about_ca_topic_score_gemma":0.00063007,"domain_scores_codex":[0.9976621,0.0006647156,0.0007321553,0.0004533017,0.0002296169,0.0002580609],"domain_scores_gemma":[0.9954776,0.002949072,0.0007698875,0.0003055019,0.0004499146,0.00004797941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002791832,0.0001034643,0.1903123,0.00007175694,0.00007917699,0.00004182626,0.005776518,0.00004036941,0.7984461,0.00003630634,0.0001706856,0.002129681],"study_design_scores_gemma":[0.008886168,0.01046519,0.8182684,0.0001594279,0.0002999253,0.00007476082,0.01101415,0.0005773017,0.1451765,0.0007157605,0.004113181,0.0002492321],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977836,0.008187937,0.000126439,0.009050297,0.0001539721,0.002250259,0.002354715,0.00002219432,0.00001825262],"genre_scores_gemma":[0.9888216,0.0003079069,0.00858323,0.00108675,0.00008148611,0.0009536758,0.0001246256,0.00002969156,0.00001104503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6532695,"threshold_uncertainty_score":0.5555611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242059657585196,"score_gpt":0.2788293535356728,"score_spread":0.2664087569598209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}