{"id":"W4289638016","doi":"10.1038/s41586-022-05022-3","title":"A non-canonical vitamin K cycle is a potent ferroptosis suppressor","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":680,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Core Research for Evolutional Science and Technology; Bundesministerium für Bildung und Forschung; Bayer Yakuhin; Helmholtz Zentrum München; Japan Society for the Promotion of Science; European Commission; Uehara Memorial Foundation; Japan Agency for Medical Research and Development; Japan Heart Foundation; Deutsche Forschungsgemeinschaft; Tohoku University Center for Gender Equality Promotion; Japan Foundation for Applied Enzymology","keywords":"Lipid peroxidation; Vitamin E; GPX4; Programmed cell death; Reductase; Chemistry; Vitamin K epoxide reductase; Apoptosis; Vitamin; Biochemistry; Antioxidant; Biology; Enzyme; Glutathione; Glutathione peroxidase; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008091145,0.0002185711,0.0001485276,0.0001269295,0.0001226161,0.0002057815,0.0002078104,0.0002205708,0.001558808],"category_scores_gemma":[0.0001145273,0.0000719704,0.00006862492,0.00006656883,0.0002075288,0.0001383945,0.0001943504,0.0002191186,0.0004499586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002811085,"about_ca_system_score_gemma":0.000154784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002364469,"about_ca_topic_score_gemma":0.0003140461,"domain_scores_codex":[0.9999343,0.00001077621,0.000003199102,0.00001791286,0.00002394725,0.000009831298],"domain_scores_gemma":[0.999939,0.00001019248,0.00001787625,0.0000060942,0.00001281526,0.00001401168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002716114,0.00002771988,0.0003561499,0.0001302762,0.000007520546,0.0001731533,0.00001124746,0.0001350188,0.988111,0.0009487841,0.0004754403,0.009352061],"study_design_scores_gemma":[0.00003851626,0.0003166143,0.003178119,0.00001067569,0.00001319388,0.001455342,0.00001578198,0.0009181225,0.9572552,0.0005597398,0.03623432,0.000004305608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9450624,0.02825639,0.01553702,0.0007504699,0.0001871195,0.00007077953,0.0006832695,0.0005259807,0.00892663],"genre_scores_gemma":[0.9878186,0.003082691,0.00176563,0.00007463039,0.00001702368,0.00001625353,0.0003412489,0.00001255554,0.00687121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001558808,"threshold_uncertainty_score":0.005214751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005471207627442567,"score_gpt":0.2474807229924669,"score_spread":0.2420095153650243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}