{"id":"W4289653616","doi":"10.1101/2022.08.02.22278185","title":"Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; IXICO; H. Lundbeck A/S; Genentech; Vlaamse regering; Servier; Innovative Medicines Initiative; Vetenskapsrådet; Eisai; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Eli Lilly and Company; U.S. Department of Defense; Eusko Jaurlaritza; Alzheimer's Association; Universiteit Antwerpen; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Research Foundation; European Federation of Pharmaceutical Industries and Associations; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; European Commission; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Foundation for the National Institutes of Health","keywords":"Genome-wide association study; Neurogranin; Biomarker; Apolipoprotein E; Genetic association; Disease; Single-nucleotide polymorphism; Biology; Oncology; Internal medicine; Bioinformatics; Genetics; Medicine; Genotype; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001975327,0.0007681678,0.0006342041,0.000727508,0.0004063747,0.0008617612,0.0006690868,0.0005163117,0.003195861],"category_scores_gemma":[0.004465119,0.0002672241,0.001702867,0.00121156,0.000550086,0.0002757438,0.0008133849,0.0008522897,0.0002406261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002809016,"about_ca_system_score_gemma":0.0003729053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005793912,"about_ca_topic_score_gemma":0.003771579,"domain_scores_codex":[0.9985464,0.0005165287,0.0001155044,0.0005215508,0.0001788139,0.0001211677],"domain_scores_gemma":[0.9967957,0.001142789,0.0009236306,0.0006151395,0.0002241289,0.0002986646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001564616,0.00005688777,0.9845577,0.00003660642,0.001557711,0.0003863627,0.00010832,0.0006480748,0.006611926,0.0002560989,0.0002849053,0.003930797],"study_design_scores_gemma":[0.00008297315,0.0001244004,0.9936178,0.00001243506,0.0005591634,0.0005116853,0.00008795076,0.002965792,0.001042246,0.0007140288,0.0002698199,0.00001167266],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997245,0.000308332,0.001375334,0.0001754994,0.0000173908,0.000006724283,0.0004935081,0.00002935316,0.0003490722],"genre_scores_gemma":[0.9991407,0.00004677374,0.00045553,0.00002564992,0.0000096702,0.000003625972,0.0002072393,0.000007481643,0.0001033621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005793912,"threshold_uncertainty_score":0.01152033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06769613827800366,"score_gpt":0.3498746836688975,"score_spread":0.2821785453908938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}