{"id":"W4289654240","doi":"10.1002/mds.29157","title":"Epigenetic Clock Acceleration Is Linked to Age at Onset of Parkinson's Disease","year":2022,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University of Toronto; Occupational Cancer Research Centre; Toronto Western Hospital","funders":"National Natural Science Foundation of China; Fundamental Research Funds for the Central Universities; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"dNaM; Cohort; Proportional hazards model; Hazard ratio; Medicine; Age of onset; Cohort study; Internal medicine; Demography; Oncology; Pediatrics; Disease; Biology; Genetics; Confidence interval; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003035025,0.0002006136,0.0002413736,0.0004372323,0.0001276464,0.0003285379,0.0001719546,0.0002552197,0.001538173],"category_scores_gemma":[0.001469305,0.0001183176,0.0002331427,0.0004390066,0.0001220663,0.0001529863,0.0002304173,0.0002301521,0.0001531084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001737602,"about_ca_system_score_gemma":0.0001342901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001933344,"about_ca_topic_score_gemma":0.001810834,"domain_scores_codex":[0.9998577,0.00002513146,0.0000149808,0.00006691825,0.0000197249,0.00001561079],"domain_scores_gemma":[0.9989698,0.0001780085,0.0006045415,0.00007632772,0.00009611349,0.00007534005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000881476,0.00002612253,0.9801272,0.00003255242,0.000108432,0.0001119714,0.00006336594,0.0001799147,0.01052434,0.00005761221,0.0001417076,0.007745336],"study_design_scores_gemma":[0.000004052491,0.00007730422,0.9984211,0.000003018261,0.0000269028,0.0001861464,0.00001750745,0.0002564923,0.0007907127,0.0000561298,0.0001578946,0.000002670061],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979114,0.0005162065,0.000526025,0.00003108039,0.000008377501,0.000004921254,0.0007127993,0.00002006521,0.0002690493],"genre_scores_gemma":[0.9990698,0.0001280848,0.0002388336,0.00001256365,0.000006759537,0.000003697589,0.0003250988,0.000003749883,0.0002114982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001933344,"threshold_uncertainty_score":0.005145729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0183013410220347,"score_gpt":0.2640493367510774,"score_spread":0.2457479957290427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}