{"id":"W4289731788","doi":"10.3390/pathogens11080875","title":"Poxviral ANKR/F-box Proteins: Substrate Adapters for Ubiquitylation and More","year":2022,"lang":"en","type":"review","venue":"Pathogens","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Skp1; Cullin; Biology; Ankyrin repeat; Ubiquitin; F-box protein; Genome; Cell biology; Innate immune system; Ubiquitin-Protein Ligases; Protein subunit; Ubiquitin ligase; Gene; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003503354,0.0007586032,0.0007837942,0.002049471,0.0002392259,0.001010582,0.0006181502,0.0008514719,0.003710268],"category_scores_gemma":[0.0004086426,0.0002143085,0.0003126924,0.001989889,0.0003165115,0.001493805,0.0005714521,0.001301698,0.003123381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005423413,"about_ca_system_score_gemma":0.0007597817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005438135,"about_ca_topic_score_gemma":0.001010622,"domain_scores_codex":[0.9999021,0.00001348942,0.00001458666,0.00002001368,0.00003660258,0.00001326247],"domain_scores_gemma":[0.9998657,0.00004407128,0.00001947247,0.00000588547,0.00004293557,0.00002207677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006181676,0.00005326555,0.0001245313,0.01058415,0.00005363168,0.0002348696,0.00005151672,0.0002761846,0.002755833,0.004531088,0.04625414,0.9350189],"study_design_scores_gemma":[0.000004714022,0.00002723832,0.0002827292,0.000898627,0.000023053,0.0007086314,0.00001970758,0.00003258829,0.0002936276,0.0008372,0.9968643,0.000007549454],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001250758,0.9971874,0.0001659927,0.0002905549,0.0003919075,0.000003575638,0.00002284687,0.00001084999,0.001801873],"genre_scores_gemma":[0.0006112594,0.9971592,0.0002365773,0.0002146535,0.0002053519,0.000005116096,0.0000566837,0.00000271584,0.001508331],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003710268,"threshold_uncertainty_score":0.01241207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05982018296352331,"score_gpt":0.3138281219073728,"score_spread":0.2540079389438495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}