{"id":"W4289774638","doi":"10.1128/mbio.02064-22","title":"Genistein Targets STING-Driven Antiviral Responses","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Australian Research Council; Fonds de Recherche du Québec - Santé; Fonds de recherche du Québec; Department of Education and Training","keywords":"Sting; Genistein; Stimulator of interferon genes; Interferon; Biology; Signal transduction; Cell biology; Pharmacology; Virology; Biochemistry; Innate immune system; Receptor; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000106765,0.0004024267,0.0002400683,0.000227733,0.0001365994,0.0002605534,0.0001357643,0.000294377,0.00139377],"category_scores_gemma":[0.00008888212,0.00006417165,0.0001928289,0.00009194583,0.0001468354,0.0001560163,0.0001491114,0.0005343732,0.0005013071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003163687,"about_ca_system_score_gemma":0.0002180923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002493502,"about_ca_topic_score_gemma":0.000741697,"domain_scores_codex":[0.9998893,0.00002196708,0.000006216957,0.0000232888,0.00002345591,0.0000357996],"domain_scores_gemma":[0.9999446,0.00001484318,0.00001307348,0.000007272145,0.000007484635,0.00001271168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007881351,0.00001131782,0.00007015457,0.0000254784,0.000001805011,0.0000176136,0.000004648465,0.0000327475,0.9988231,0.00004407019,0.00001734081,0.0008729228],"study_design_scores_gemma":[0.000005471449,0.0001899353,0.001603953,0.000004685324,0.000005160284,0.00007469115,0.00001137066,0.0002323377,0.9960442,0.00003693107,0.001789888,0.000001529275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824486,0.005281387,0.00501937,0.0002103597,0.00007948359,0.00007004469,0.0006587942,0.0001820599,0.006049753],"genre_scores_gemma":[0.9932429,0.001826771,0.001682097,0.00006462007,0.00002106608,0.00002563938,0.0004521351,0.00001631992,0.002668415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00139377,"threshold_uncertainty_score":0.004662633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01517751374808868,"score_gpt":0.2468557352866167,"score_spread":0.231678221538528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}