{"id":"W4289779036","doi":"10.1016/j.cgh.2022.07.024","title":"Safety and Sustained Efficacy of the Farnesoid X Receptor (FXR) Agonist Cilofexor Over a 96-Week Open-label Extension in Patients With PSC","year":2022,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital","funders":"Gilead Sciences","keywords":"Medicine; Internal medicine; Interquartile range; Farnesoid X receptor; Ursodeoxycholic acid; Gastroenterology; Obeticholic acid; Hepatology; Primary sclerosing cholangitis; Autoimmune hepatitis; Alkaline phosphatase; Bile acid; Hepatitis; Agonist; Receptor; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001071397,0.0004608149,0.001343956,0.0002389015,0.0002708637,0.0007730809,0.0002808837,0.0006998772,0.002343724],"category_scores_gemma":[0.001360922,0.0002234941,0.001008614,0.0002709484,0.0004872955,0.001028733,0.0002388815,0.001923684,0.0004690241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004085433,"about_ca_system_score_gemma":0.0004708962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004427177,"about_ca_topic_score_gemma":0.0005388422,"domain_scores_codex":[0.9995896,0.0001515747,0.00004031157,0.00008181099,0.0000501367,0.00008660161],"domain_scores_gemma":[0.9994584,0.0001173311,0.0001609519,0.00006699264,0.00004486419,0.0001513684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8029552,0.009427285,0.009125211,0.0005528925,0.0006381013,0.0002655311,0.0001488092,0.001490536,0.04728634,0.0001235275,0.000906601,0.12708],"study_design_scores_gemma":[0.1849537,0.6181295,0.1588586,0.0001547874,0.001808207,0.001027312,0.0003140226,0.004243648,0.02490024,0.0003272281,0.005136879,0.0001458374],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967929,0.001932405,0.000233207,0.0001296896,0.00004428111,0.00009825009,0.0002803215,0.00004020725,0.0004487319],"genre_scores_gemma":[0.9983902,0.0003945798,0.000238212,0.00009524596,0.00004942116,0.00008470858,0.0002669602,0.000005787301,0.0004748856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002343724,"threshold_uncertainty_score":0.007840514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03158967637287408,"score_gpt":0.3145507385371378,"score_spread":0.2829610621642638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}