{"id":"W4289779036","doi":"10.1016/j.cgh.2022.07.024","title":"Safety and Sustained Efficacy of the Farnesoid X Receptor (FXR) Agonist Cilofexor Over a 96-Week Open-label Extension in Patients With PSC","year":2022,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital","funders":"Gilead Sciences","keywords":"Medicine; Internal medicine; Interquartile range; Farnesoid X receptor; Ursodeoxycholic acid; Gastroenterology; Obeticholic acid; Hepatology; Primary sclerosing cholangitis; Autoimmune hepatitis; Alkaline phosphatase; Bile acid; Hepatitis; Agonist; Receptor; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005154808,0.0001500025,0.0006739919,0.00005666246,0.0002149511,0.000006187171,0.0002236237,0.0001057939,0.0001545402],"category_scores_gemma":[0.0002401944,0.0001012101,0.00005741297,0.0001060006,0.0008177217,0.00003642146,0.0009818149,0.0006055962,9.257349e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003816853,"about_ca_system_score_gemma":0.0001134874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001079609,"about_ca_topic_score_gemma":0.00006803255,"domain_scores_codex":[0.9977356,0.0008471481,0.0005923126,0.0003964406,0.0001132651,0.0003152695],"domain_scores_gemma":[0.9988469,0.0003007147,0.0002382307,0.0003986177,0.00008308009,0.0001324187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04609008,0.003764482,0.9483719,0.00003050588,0.00009857692,0.00001625388,0.00008261537,6.438163e-7,0.00001372392,0.0001029533,0.0005156283,0.0009126528],"study_design_scores_gemma":[0.02861702,0.01065312,0.9586903,0.0000260633,0.0001194746,0.00003308288,0.0001808314,0.00007753215,0.000001170968,0.00004341834,0.001498449,0.00005955217],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957305,0.0001348321,0.000006549188,0.003112647,0.0002203417,0.0006969272,0.00005244198,0.000007286122,0.00003852864],"genre_scores_gemma":[0.9951186,0.0001051121,0.00008638112,0.004494646,0.00001797473,0.00002133127,0.00005111739,0.00001316289,0.00009172001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01747306,"threshold_uncertainty_score":0.4127227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03158967637287408,"score_gpt":0.3145507385371378,"score_spread":0.2829610621642638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}