{"id":"W4289783372","doi":"10.1038/s41467-022-32232-0","title":"A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Amsterdam University Medical Centers; Bill and Melinda Gates Foundation","keywords":"Epitope; Spike (software development); Spike Protein; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Coronavirus disease 2019 (COVID-19); Antibody; 2019-20 coronavirus outbreak; Computational biology; Biology; Genetics; Computer science; Medicine; Outbreak; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001608426,0.0002253351,0.0002044753,0.0003076773,0.0002308919,0.0003556064,0.0001894002,0.000380168,0.005675091],"category_scores_gemma":[0.000188551,0.0001076263,0.0002074811,0.0001670045,0.0001989157,0.0002828926,0.0003141497,0.0003207178,0.0008414469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002801637,"about_ca_system_score_gemma":0.000137005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004532354,"about_ca_topic_score_gemma":0.0005364706,"domain_scores_codex":[0.9998538,0.00001346284,0.000007027081,0.00004117864,0.00003378932,0.00005071991],"domain_scores_gemma":[0.9998727,0.00002772161,0.00002820684,0.00002306531,0.00002592387,0.00002236905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001510309,0.00006272764,0.01088636,0.00003842045,0.00001174158,0.00009812287,0.00007243246,0.00009271527,0.979362,0.0003871878,0.000190556,0.008646696],"study_design_scores_gemma":[0.0000972953,0.001921198,0.3227052,0.00005271306,0.000104766,0.004316621,0.0005672547,0.005372806,0.6392776,0.001204281,0.02435711,0.00002311149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993835,0.0002508605,0.002041256,0.00005581994,0.000007777488,0.00002250512,0.0001978856,0.00008242307,0.003506462],"genre_scores_gemma":[0.997358,0.0001305422,0.0006941289,0.00006981603,0.00001076251,0.0000123214,0.0003181662,0.00001078146,0.001395496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005675091,"threshold_uncertainty_score":0.01898503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2002102826164986,"score_gpt":0.4508373564327903,"score_spread":0.2506270738162916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}