{"id":"W4289783402","doi":"10.1021/acs.estlett.2c00431","title":"Exposure to the Tire Rubber-Derived Contaminant 6PPD-Quinone Causes Mitochondrial Dysfunction <i>In Vitro</i>","year":2022,"lang":"en","type":"article","venue":"Environmental Science & Technology Letters","topic":"Environmental Toxicology and Ecotoxicology","field":"Environmental Science","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Global Institute for Water Security; University of Lethbridge; University of Saskatchewan","funders":"Western Economic Diversification Canada; Canada Research Chairs; Canada First Research Excellence Fund; Natural Sciences and Engineering Research Council of Canada; Fisheries and Oceans Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Canada Foundation for Innovation","keywords":"Quinone; Rainbow trout; Metabolite; Cytotoxicity; Respiration; Biochemistry; Biology; Viability assay; Mitochondrion; Toxicity; In vitro; Chemistry; Anatomy; Fish <Actinopterygii>; Fishery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":["sts","insufficient_payload"],"category_scores_codex":[0.0007653459,0.0003659983,0.0003184721,0.000445629,0.002245643,0.00003827414,0.001687781,0.0001678549,0.005215699],"category_scores_gemma":[0.00004337837,0.0003240748,0.00008925333,0.001836738,0.004135481,0.0003718281,0.002729956,0.0008888135,0.00145321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002262434,"about_ca_system_score_gemma":0.0000197204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008061243,"about_ca_topic_score_gemma":0.0001875262,"domain_scores_codex":[0.9960996,0.0002134308,0.0004509127,0.001236491,0.0008088145,0.001190767],"domain_scores_gemma":[0.9987697,0.00007075568,0.0001734106,0.0008078681,9.351785e-7,0.0001773577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001340858,0.000295084,0.03160826,7.980807e-7,0.00000776707,0.00009722367,0.0004037652,0.005065664,0.954616,0.00002202606,0.001908102,0.00584126],"study_design_scores_gemma":[0.002370897,0.001615373,0.1897506,0.000006874047,0.0000435051,0.0005160256,0.004160542,0.0002874655,0.6636708,0.0001253718,0.1363886,0.001063928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817736,0.0000483698,0.0001000699,0.0152981,0.001112088,0.001053023,0.00003406787,0.0001062446,0.0004744955],"genre_scores_gemma":[0.9878219,0.00001736341,0.0006033385,0.009997928,0.00005908894,0.0008540729,0.00001438481,0.00003075813,0.0006011656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2909452,"threshold_uncertainty_score":0.9999211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004472143848345769,"score_gpt":0.187886693514391,"score_spread":0.1834145496660452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}