{"id":"W4289783402","doi":"10.1021/acs.estlett.2c00431","title":"Exposure to the Tire Rubber-Derived Contaminant 6PPD-Quinone Causes Mitochondrial Dysfunction <i>In Vitro</i>","year":2022,"lang":"en","type":"article","venue":"Environmental Science & Technology Letters","topic":"Environmental Toxicology and Ecotoxicology","field":"Environmental Science","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Global Institute for Water Security; University of Lethbridge; University of Saskatchewan","funders":"Western Economic Diversification Canada; Canada Research Chairs; Canada First Research Excellence Fund; Natural Sciences and Engineering Research Council of Canada; Fisheries and Oceans Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Canada Foundation for Innovation","keywords":"Quinone; Rainbow trout; Metabolite; Cytotoxicity; Respiration; Biochemistry; Biology; Viability assay; Mitochondrion; Toxicity; In vitro; Chemistry; Anatomy; Fish <Actinopterygii>; Fishery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001924344,0.0004180247,0.0002802321,0.0001288671,0.0001602639,0.000303468,0.0002284424,0.0003555325,0.00113028],"category_scores_gemma":[0.0001624164,0.0001815143,0.0004271281,0.0001363475,0.0002323984,0.0001830486,0.0002642706,0.0003963388,0.0004696769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003162906,"about_ca_system_score_gemma":0.0002520629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005135634,"about_ca_topic_score_gemma":0.00535257,"domain_scores_codex":[0.9997219,0.00003845298,0.00003205368,0.00007523517,0.00007368364,0.00005864721],"domain_scores_gemma":[0.9998454,0.00002474826,0.0000485559,0.00002518283,0.00003915375,0.00001700235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008628225,0.0000170671,0.0006448824,0.00003151536,0.000006965929,0.00006593821,0.00002128107,0.00004531323,0.9986007,0.00001133082,0.00003714416,0.0004315886],"study_design_scores_gemma":[0.000004860665,0.0009845251,0.01191624,0.000006630652,0.0000200122,0.0002192567,0.00008730972,0.0005470495,0.9853603,0.00001392087,0.00083335,0.000006512649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961052,0.0005222179,0.001781331,0.00006389588,0.00002409522,0.00002459246,0.0006026975,0.00005531922,0.0008206859],"genre_scores_gemma":[0.994153,0.0006168421,0.001731445,0.00006860703,0.000006457545,0.00003638587,0.00145877,0.00001174308,0.001916836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005135634,"threshold_uncertainty_score":0.01021147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004472143848345769,"score_gpt":0.187886693514391,"score_spread":0.1834145496660452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}