{"id":"W4289786895","doi":"10.1261/rna.079125.122","title":"Positive strand RNA viruses differ in the constraints they place on the folding of their negative strand","year":2022,"lang":"en","type":"article","venue":"RNA","topic":"Hepatitis C virus research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Medical Research Council Canada; Royal Society","keywords":"Biology; Ribozyme; RNA; RNA-dependent RNA polymerase; Virology; Polymerase; RNA virus; Viral replication; Coding strand; Virus; RNA polymerase; Genetics; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004422088,0.0002629341,0.0002803275,0.000279774,0.000217763,0.0008890015,0.0002200159,0.0003908083,0.001281093],"category_scores_gemma":[0.0008723132,0.0001961153,0.0002501617,0.0001915341,0.0004594106,0.0004541609,0.000284677,0.0004279648,0.000499032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001814838,"about_ca_system_score_gemma":0.0002432412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002084281,"about_ca_topic_score_gemma":0.0004528437,"domain_scores_codex":[0.9995272,0.0001040861,0.00004152027,0.00008749864,0.0001906126,0.00004915583],"domain_scores_gemma":[0.9992318,0.0003252222,0.0002114978,0.00007986712,0.00008210375,0.00006947405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009501274,0.00001891935,0.002699924,0.00008868195,0.0000119667,0.00006330523,0.00007243596,0.0001569733,0.9920844,0.0008925646,0.0000222921,0.003793617],"study_design_scores_gemma":[0.00002428032,0.0009140454,0.05139356,0.00007396896,0.00008394846,0.00246905,0.0004518221,0.001362268,0.9245867,0.002593804,0.01599419,0.00005233997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830458,0.003442295,0.008301876,0.00009433278,0.00005258939,0.00002787204,0.0001773359,0.00004940048,0.004808502],"genre_scores_gemma":[0.9897082,0.001304193,0.007074335,0.0001269146,0.00002242925,0.00002935952,0.0003311266,0.00002755516,0.001375855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001281093,"threshold_uncertainty_score":0.004285634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05689490386244787,"score_gpt":0.324607620226569,"score_spread":0.2677127163641211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}