{"id":"W4289786895","doi":"10.1261/rna.079125.122","title":"Positive strand RNA viruses differ in the constraints they place on the folding of their negative strand","year":2022,"lang":"en","type":"article","venue":"RNA","topic":"Hepatitis C virus research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Medical Research Council Canada; Royal Society","keywords":"Biology; Ribozyme; RNA; RNA-dependent RNA polymerase; Virology; Polymerase; RNA virus; Viral replication; Coding strand; Virus; RNA polymerase; Genetics; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009246999,0.0001372261,0.0002459469,0.0000993538,0.0002229533,0.00002277315,0.0002740118,0.00003602941,0.0008727794],"category_scores_gemma":[0.0002885418,0.00007143442,0.00008669473,0.0002260631,0.0002829443,0.00004158286,0.00006952698,0.0006774074,0.00000872688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001062465,"about_ca_system_score_gemma":0.0001441859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004288642,"about_ca_topic_score_gemma":0.0002177873,"domain_scores_codex":[0.997995,0.0006706928,0.0002243469,0.0001927897,0.0006432452,0.000273966],"domain_scores_gemma":[0.9973636,0.0021695,0.00007037558,0.0002926912,0.00005144083,0.0000523944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01011512,0.003228166,0.06948936,0.0002993711,0.001761185,0.001342572,0.2927462,0.0005437822,0.4222461,0.03480032,0.006840326,0.1565874],"study_design_scores_gemma":[0.0140171,0.005695124,0.4324442,0.001163569,0.0002234122,0.0001284759,0.1068532,0.002152205,0.4256929,0.007870399,0.002944947,0.0008144772],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687774,0.00006797747,0.00001246361,0.002568127,0.00004090443,0.0008983015,0.0003199765,0.00001045712,0.02730444],"genre_scores_gemma":[0.9986204,0.00005147902,0.00001099703,0.00109645,0.00004220597,0.00006954294,0.000006359906,0.00001774221,0.00008481077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3629549,"threshold_uncertainty_score":0.9556322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05689490386244787,"score_gpt":0.324607620226569,"score_spread":0.2677127163641211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}