{"id":"W4289793990","doi":"10.1021/acs.molpharmaceut.2c00457","title":"Panitumumab-DOTA-<sup>111</sup>In: An Epidermal Growth Factor Receptor Targeted Theranostic for SPECT/CT Imaging and Meitner–Auger Electron Radioimmunotherapy of Triple-Negative Breast Cancer","year":2022,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto; Canadian Institutes of Health Research; Amgen Canada; Terry Fox Foundation","keywords":"Radioimmunotherapy; Triple-negative breast cancer; DOTA; Cancer research; Nuclear medicine; Epidermal growth factor receptor; Medicine; Oncology; Breast cancer; Chemistry; Cancer; Internal medicine; Immunology; Chelation; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001609,0.0002916027,0.0004552671,0.0002044319,0.0001940198,0.00002370186,0.0001155415,0.00001729661,0.0005310685],"category_scores_gemma":[0.00002749442,0.0002732273,0.0001417406,0.000335363,0.0000955694,0.0001329,0.0000350794,0.0003022316,8.979482e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005182221,"about_ca_system_score_gemma":0.000319337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000322379,"about_ca_topic_score_gemma":0.000009262836,"domain_scores_codex":[0.9982237,0.0002115811,0.0003827896,0.0004142406,0.0003153997,0.0004523474],"domain_scores_gemma":[0.9992278,0.0001030972,0.0001636462,0.000220458,0.0001444076,0.0001405665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005427851,0.001976207,0.05171849,0.0004136183,0.002577568,0.0005023711,0.009624167,0.0020565,0.8912811,0.0005052544,0.0007144684,0.03320245],"study_design_scores_gemma":[0.05096593,0.001905634,0.03006558,0.0001843654,0.00236169,0.0008522267,0.002612988,0.045712,0.8518422,0.0007369812,0.01147277,0.00128766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863864,0.007693528,0.0005438101,0.002084248,0.0002070388,0.001916557,0.001034769,0.00005085529,0.00008276029],"genre_scores_gemma":[0.9963955,0.0006080341,0.0006163821,0.001401952,0.00007807073,0.0004467339,0.0002048222,0.00009103034,0.0001574411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04553808,"threshold_uncertainty_score":0.999972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01749404528460903,"score_gpt":0.3504188063991546,"score_spread":0.3329247611145456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}