{"id":"W4289820683","doi":"10.1200/jco.2022.40.17_suppl.lba8511","title":"Neoadjuvant nivolumab (NIVO) + platinum-doublet chemotherapy (chemo) versus chemo for resectable (IB–IIIA) non-small cell lung cancer (NSCLC): Association of pathological regression with event-free survival (EFS) in CheckMate 816.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Pathological; Clinical endpoint; Internal medicine; Oncology; Nivolumab; Lung cancer; Neoadjuvant therapy; Receiver operating characteristic; Post-hoc analysis; Stage (stratigraphy); Chemotherapy; non-small cell lung cancer (NSCLC); Surrogate endpoint; Cancer; Clinical trial; Immunotherapy; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002306952,0.0008179347,0.001373906,0.0002712754,0.0002973687,0.0006244313,0.0007828178,0.001071632,0.002830919],"category_scores_gemma":[0.001600942,0.0003714132,0.001528147,0.0002811685,0.0008161223,0.0005536859,0.0004995679,0.002144767,0.0003911639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001039657,"about_ca_system_score_gemma":0.001380827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009494391,"about_ca_topic_score_gemma":0.003613229,"domain_scores_codex":[0.9993203,0.0003595911,0.00005144795,0.0001195706,0.00005633234,0.00009275329],"domain_scores_gemma":[0.9981516,0.0005641032,0.0004871372,0.0001407353,0.00006628899,0.0005901521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9641032,0.01061207,0.004529978,0.0002445533,0.0006062207,0.0000323265,0.00004718034,0.0004815132,0.006911572,0.00005041179,0.0004853063,0.01189566],"study_design_scores_gemma":[0.3559552,0.6025779,0.033384,0.00004894323,0.001630911,0.00007873424,0.00004556085,0.001357088,0.003577649,0.0001207888,0.001186483,0.00003663124],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979164,0.0005177701,0.0001137457,0.00009364334,0.0000571097,0.000505187,0.0003922205,0.00001357521,0.0003903801],"genre_scores_gemma":[0.9962365,0.0003766518,0.0004993237,0.0003310748,0.0001282244,0.0007617328,0.0008011666,0.000007608407,0.0008577167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002830919,"threshold_uncertainty_score":0.01220047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06948997712028145,"score_gpt":0.4151919174606839,"score_spread":0.3457019403404025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}