{"id":"W4289837534","doi":"10.1128/mbio.01456-22","title":"TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Inflammation biomarkers and pathways","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"TREM2; Macrophage; Immune system; Mycobacterium tuberculosis; Microbiology; Biology; Tumor necrosis factor alpha; Intracellular parasite; Interferon; Interferon gamma; Immunology; Tuberculosis; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003069217,0.0001234113,0.0001722067,0.0001010168,0.0003924758,0.00001428069,0.0001680199,0.0001010472,0.005406888],"category_scores_gemma":[0.00001088642,0.0001202117,0.00006933769,0.000152863,0.00006056647,0.00005445407,0.00014452,0.0002338698,0.0001375584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007073932,"about_ca_system_score_gemma":0.00001628205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002592656,"about_ca_topic_score_gemma":0.00001906749,"domain_scores_codex":[0.9989841,0.0002339831,0.0002705974,0.0002211327,0.00003678812,0.0002533803],"domain_scores_gemma":[0.9996624,0.00002730163,0.00008043513,0.0002019291,0.00001743699,0.00001051021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005921935,0.000123483,0.00316925,0.00001084344,0.00003086701,0.000008477449,0.0005210432,7.632784e-7,0.985878,0.0001115518,0.007635343,0.002451144],"study_design_scores_gemma":[0.001520883,0.0002993071,0.03206408,0.00001563186,0.00001526975,0.00004774539,0.000364867,0.00000463361,0.8654866,0.0001506244,0.09977168,0.0002586542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944061,0.002132659,0.000003467801,0.000376282,0.0004652931,0.0002173639,0.0001314983,0.00005607911,0.002211225],"genre_scores_gemma":[0.9940099,0.00002101667,0.00001187539,0.0000870412,0.0000132319,0.000072761,0.0008464824,0.00001269536,0.004925027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1203914,"threshold_uncertainty_score":0.9955023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008064053803715535,"score_gpt":0.2151743516013237,"score_spread":0.2071102977976082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}