{"id":"W4289837534","doi":"10.1128/mbio.01456-22","title":"TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Inflammation biomarkers and pathways","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"TREM2; Macrophage; Immune system; Mycobacterium tuberculosis; Microbiology; Biology; Tumor necrosis factor alpha; Intracellular parasite; Interferon; Interferon gamma; Immunology; Tuberculosis; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004819448,0.0002571758,0.0002822089,0.0002398025,0.0002254808,0.0004396627,0.0001283308,0.0003547118,0.003989162],"category_scores_gemma":[0.0002151526,0.0001533676,0.0002617038,0.0001030243,0.0002048834,0.000179174,0.0004235429,0.0007988316,0.001100022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000137258,"about_ca_system_score_gemma":0.0002701434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000175986,"about_ca_topic_score_gemma":0.0003196205,"domain_scores_codex":[0.9997482,0.0000876926,0.00001316883,0.00002246418,0.00004308733,0.00008541093],"domain_scores_gemma":[0.9999074,0.00001264653,0.00001528099,0.00001107053,0.00001476173,0.0000389105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003344137,0.0005046439,0.00287243,0.000423476,0.00004148147,0.0009134397,0.0001493153,0.0002464208,0.9806188,0.0005551345,0.001798,0.00853272],"study_design_scores_gemma":[0.001550653,0.007745163,0.1314899,0.0002470041,0.0002087453,0.007528557,0.001159912,0.004133108,0.7974057,0.001251108,0.04722388,0.00005617634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896863,0.00527508,0.0006739037,0.0004830052,0.0001559157,0.00005211193,0.0003256719,0.00006877082,0.003279269],"genre_scores_gemma":[0.9944312,0.001500465,0.0003764753,0.0002790839,0.00008289264,0.0000504155,0.0003454019,0.000009555304,0.002924651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003989162,"threshold_uncertainty_score":0.01334506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008064053803715535,"score_gpt":0.2151743516013237,"score_spread":0.2071102977976082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}