{"id":"W4289837800","doi":"10.1016/j.jbc.2022.102320","title":"The ARSACS disease protein sacsin controls lysosomal positioning and reformation by regulating microtubule dynamics","year":2022,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; ALS Society of Canada","keywords":"Microtubule; Neurodegeneration; Biology; Axoplasmic transport; Cell biology; Spinocerebellar ataxia; Ataxia; Autophagy; Phenotype; Gene; Genetics; Neuroscience; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001118366,0.0005011881,0.0002198991,0.0002687377,0.0002459417,0.0003358395,0.0001732863,0.0003138354,0.0007112361],"category_scores_gemma":[0.0001242447,0.0001393055,0.0001848827,0.0001347083,0.0003973784,0.0001455344,0.0002217853,0.0002885927,0.0003293291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004627074,"about_ca_system_score_gemma":0.0002438091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001238544,"about_ca_topic_score_gemma":0.002171072,"domain_scores_codex":[0.999913,0.00001646594,0.00001160551,0.0000225309,0.00002302514,0.0000134367],"domain_scores_gemma":[0.999896,0.00001462384,0.00003827216,0.000009228243,0.00001298047,0.0000288333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001057905,0.000008942578,0.0007519574,0.00003319868,0.000008180799,0.0003593397,0.00002029351,0.0001680052,0.9969307,0.0002824743,0.000126126,0.001205044],"study_design_scores_gemma":[0.0000533629,0.0001821057,0.02549568,0.00001940507,0.00003888532,0.002506735,0.00007389011,0.006442211,0.9571115,0.0004645714,0.007590099,0.00002143875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99385,0.001578851,0.002758034,0.0001143606,0.00005003332,0.000009328981,0.0003166096,0.0001574899,0.001165182],"genre_scores_gemma":[0.9972047,0.0004132557,0.0008712816,0.0000237057,0.000008991958,0.000007184838,0.0001932407,0.0000171836,0.001260291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001238544,"threshold_uncertainty_score":0.003357232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004879594946932232,"score_gpt":0.1964622826097726,"score_spread":0.1915826876628404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}