{"id":"W4289841189","doi":"10.1038/s41467-022-31907-y","title":"Structural and mechanistic analysis of a tripartite ATP-independent periplasmic TRAP transporter","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Institute of Genetics; Julius-Maximilians-Universität Würzburg; Rheinische Friedrich-Wilhelms-Universität Bonn; Universität Regensburg; UK Research and Innovation; Deutsche Forschungsgemeinschaft; University of Warwick","keywords":"Periplasmic space; Trap (plumbing); Transporter; Computational biology; ATP-binding cassette transporter; Structural biology; Cell biology; Chemistry; Biology; Biochemistry; Physics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009026214,0.0001423925,0.0001513259,0.00008088275,0.0002009093,0.000256291,0.0003628857,0.0003935991,0.0004356374],"category_scores_gemma":[0.0001044484,0.00008756477,0.0002075797,0.00008975796,0.0001917524,0.000238805,0.0001468672,0.0003971468,0.0001307927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000487265,"about_ca_system_score_gemma":0.0002251034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009655075,"about_ca_topic_score_gemma":0.0006603745,"domain_scores_codex":[0.9999527,0.000008714254,0.000003871532,0.000008269142,0.0000176199,0.00000888794],"domain_scores_gemma":[0.999952,0.000007259705,0.00001181566,0.000005066182,0.000007695666,0.0000162192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001050481,0.00003948726,0.0003506814,0.00004608787,0.000008082646,0.000179691,0.00002173019,0.001723888,0.9960945,0.0006154189,0.0000409667,0.0007744064],"study_design_scores_gemma":[0.00005612028,0.0004617645,0.007907427,0.000015115,0.000045298,0.0009001455,0.0001941354,0.08069936,0.9059788,0.0006166512,0.003093873,0.00003133024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997394,0.0002506456,0.001835214,0.00007774039,0.000004823461,0.000007963508,0.00008523143,0.00001960714,0.0003246621],"genre_scores_gemma":[0.9965878,0.000251282,0.002523532,0.0000342368,0.000002299425,0.000007474699,0.0002324479,0.000005574343,0.0003554414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009655075,"threshold_uncertainty_score":0.00353539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01746879642934336,"score_gpt":0.2852385810332015,"score_spread":0.2677697846038581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}