{"id":"W4289856259","doi":"10.1038/s41392-022-01059-y","title":"Human umbilical cord mesenchymal stem cells for psoriasis: a phase 1/2a, single-arm study","year":2022,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"National Natural Science Foundation of China","keywords":"Psoriasis; Medicine; Umbilical cord; Mesenchymal stem cell; Peripheral blood mononuclear cell; Adverse effect; Immune system; Immunology; Transplantation; Interleukin 17; Internal medicine; Psoriasis Area and Severity Index; Biomarker; Gastroenterology; Pathology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002486229,0.001713639,0.003071459,0.0007363243,0.000505677,0.001007972,0.0006483698,0.001601536,0.00352616],"category_scores_gemma":[0.0008240403,0.0005965388,0.001880745,0.0005895144,0.0009936818,0.0008737039,0.0003595896,0.002511392,0.0006657769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005059562,"about_ca_system_score_gemma":0.00120649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002986345,"about_ca_topic_score_gemma":0.0006329927,"domain_scores_codex":[0.999151,0.0003561928,0.00005543796,0.0001378173,0.0001326544,0.0001669281],"domain_scores_gemma":[0.999478,0.00007990425,0.0001088919,0.00007246117,0.00004907899,0.0002116288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6157814,0.1854568,0.004124496,0.002688474,0.002558092,0.0003479978,0.0002167761,0.001491684,0.07518293,0.0003718226,0.002818841,0.1089606],"study_design_scores_gemma":[0.3794057,0.60958,0.003453832,0.0000645937,0.0006526362,0.0001489568,0.00003943814,0.0006361177,0.004276096,0.0001627343,0.001558154,0.00002165422],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837227,0.00665561,0.001539953,0.0004606277,0.0003183197,0.005676104,0.0006606013,0.0001221939,0.0008438192],"genre_scores_gemma":[0.9744318,0.005926015,0.004112554,0.002059113,0.0006609416,0.008477097,0.001337199,0.00004673488,0.002948581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00352616,"threshold_uncertainty_score":0.01314861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0487887199434547,"score_gpt":0.2857586974476647,"score_spread":0.23696997750421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}