{"id":"W4289856259","doi":"10.1038/s41392-022-01059-y","title":"Human umbilical cord mesenchymal stem cells for psoriasis: a phase 1/2a, single-arm study","year":2022,"lang":"en","type":"article","venue":"Signal Transduction and Targeted Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"National Natural Science Foundation of China","keywords":"Psoriasis; Medicine; Umbilical cord; Mesenchymal stem cell; Peripheral blood mononuclear cell; Adverse effect; Immune system; Immunology; Transplantation; Interleukin 17; Internal medicine; Psoriasis Area and Severity Index; Biomarker; Gastroenterology; Pathology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003559982,0.0002819907,0.0003797147,0.0001555115,0.001033757,0.00002589084,0.000151352,0.0001218759,0.003438395],"category_scores_gemma":[0.000001150726,0.0002584921,0.0002058777,0.0002095783,0.0001029415,0.00008321343,0.00001645029,0.0002252294,0.00001254397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005025236,"about_ca_system_score_gemma":0.00003409898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003558248,"about_ca_topic_score_gemma":0.00001046374,"domain_scores_codex":[0.9981269,0.000531434,0.0003567775,0.0005354399,0.00008481933,0.0003646917],"domain_scores_gemma":[0.9995201,0.00008055465,0.0001036578,0.0001930398,0.00005363755,0.00004899608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005158063,0.007988072,0.0001734289,0.000008523435,0.0008462526,0.000008014965,0.002553153,0.0000121422,0.8520115,0.0001473755,0.0004180105,0.1306755],"study_design_scores_gemma":[0.05046697,0.04451916,0.0007407421,0.000007729232,0.0004717362,0.0001068375,0.01064824,0.0000152141,0.8134506,0.0005721435,0.07823739,0.0007632588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928268,0.003436649,0.000255952,0.0001375624,0.001419561,0.001449721,0.0002728039,0.0001422109,0.00005877341],"genre_scores_gemma":[0.9975167,0.00007063749,0.00004108333,0.00009709893,0.00013105,0.0006208295,0.0001824764,0.00003553718,0.001304599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1299122,"threshold_uncertainty_score":0.9999867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0487887199434547,"score_gpt":0.2857586974476647,"score_spread":0.23696997750421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}