{"id":"W4289866368","doi":"10.1016/j.biopsych.2022.07.019","title":"Sex-Specific Genetic and Transcriptomic Liability to Neuroticism","year":2022,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Janssen Research and Development; National Institutes of Health; One Mind; Eisai Canada; National Institute on Alcohol Abuse and Alcoholism; Greenwich Biosciences; ACADIA Pharmaceuticals; American Heart Association; Sunovion; National Institute on Deafness and Other Communication Disorders; National Institute on Drug Abuse; AstraZeneca; National Institute of Mental Health; Medical Research Council","keywords":"Neuroticism; Etiology; Transcriptome; Psychology; Clinical psychology; Genome-wide association study; Association (psychology); Psychiatry; Medicine; Biology; Genetics; Personality; Single-nucleotide polymorphism; Gene; Psychotherapist; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000358296,0.000154893,0.0002024191,0.00003343364,0.0002575874,0.00001003123,0.0002269213,0.0001258315,0.0001518116],"category_scores_gemma":[0.00005894934,0.000136749,0.00009522065,0.0001056366,0.00008109143,8.052364e-7,0.0002227192,0.0001586652,0.0000136623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001675922,"about_ca_system_score_gemma":0.00003679572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008683893,"about_ca_topic_score_gemma":0.000008840108,"domain_scores_codex":[0.9983873,0.000344692,0.0002779023,0.0005961547,0.00007921099,0.0003146867],"domain_scores_gemma":[0.9994388,0.00002675465,0.00005362322,0.0003229547,0.00001939026,0.0001384571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001535567,0.0002575302,0.9073955,0.000007084246,0.00003799368,0.000001669266,0.00006405936,0.0005242978,0.05999874,0.0006882458,0.02461066,0.006260604],"study_design_scores_gemma":[0.0003351052,0.001058411,0.822105,7.536549e-7,0.000006187671,0.000027267,0.0001527204,0.00003043569,0.00007904308,0.001970979,0.17402,0.0002141318],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925739,0.001705524,0.001525411,0.002592001,0.0007353908,0.000301184,0.00005587851,0.00002225699,0.0004884808],"genre_scores_gemma":[0.9889889,0.0001790335,0.006442774,0.003694801,0.0002633428,0.0001049026,0.00004645235,0.00001312915,0.0002666813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1494093,"threshold_uncertainty_score":0.5576465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239194797219317,"score_gpt":0.2565895137521701,"score_spread":0.2341975657799769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}