{"id":"W4289866368","doi":"10.1016/j.biopsych.2022.07.019","title":"Sex-Specific Genetic and Transcriptomic Liability to Neuroticism","year":2022,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Janssen Research and Development; National Institutes of Health; One Mind; Eisai Canada; National Institute on Alcohol Abuse and Alcoholism; Greenwich Biosciences; ACADIA Pharmaceuticals; American Heart Association; Sunovion; National Institute on Deafness and Other Communication Disorders; National Institute on Drug Abuse; AstraZeneca; National Institute of Mental Health; Medical Research Council","keywords":"Neuroticism; Etiology; Transcriptome; Psychology; Clinical psychology; Genome-wide association study; Association (psychology); Psychiatry; Medicine; Biology; Genetics; Personality; Single-nucleotide polymorphism; Gene; Psychotherapist; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002233178,0.0002967921,0.0001903694,0.0008008284,0.0002637644,0.0004145707,0.0001939711,0.0003340014,0.004743153],"category_scores_gemma":[0.00100831,0.0001602192,0.0003542992,0.0005549026,0.0002402295,0.0001472274,0.0003378324,0.0003487492,0.0003152138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001138646,"about_ca_system_score_gemma":0.0001342578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001398227,"about_ca_topic_score_gemma":0.001618981,"domain_scores_codex":[0.9997277,0.00007009132,0.00002162301,0.00008797173,0.00004459046,0.00004806177],"domain_scores_gemma":[0.9992488,0.0002076299,0.0002863339,0.0000755296,0.0000621177,0.0001195547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001199416,0.000100469,0.8791745,0.00004047464,0.0003979646,0.002220371,0.0004820895,0.0002160164,0.1064298,0.0005417668,0.0002775526,0.008919554],"study_design_scores_gemma":[0.000005840162,0.0000596666,0.9973521,0.000003898978,0.00004101588,0.0008581393,0.00008929673,0.0001317464,0.001112112,0.000201485,0.000140299,0.000004416495],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984105,0.0001352498,0.0003000209,0.00007216127,0.00000917875,0.000002703091,0.0004463036,0.000008112177,0.0006156441],"genre_scores_gemma":[0.9983467,0.0000936011,0.0001965985,0.00003145586,0.00001444322,0.000004345309,0.0002927048,0.00001083725,0.001009514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004743153,"threshold_uncertainty_score":0.01586747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239194797219317,"score_gpt":0.2565895137521701,"score_spread":0.2341975657799769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}