{"id":"W4289868958","doi":"10.1161/jaha.121.025045","title":"Effect of Canagliflozin on Total Cardiovascular Burden in Patients With Diabetes and Chronic Kidney Disease: A Post Hoc Analysis From the CREDENCE Trial","year":2022,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; University of British Columbia","funders":"Relypsa; National Health and Medical Research Council; Medical Research Council; Akebia Therapeutics; Mitsubishi Tanabe Pharma Corporation; Servier; Novo Nordisk; Eisai; Innovent Biologics; Amarin Corporation; Regeneron Pharmaceuticals; Heart Research Australia; Alnylam Pharmaceuticals; Daiichi Sankyo Europe; Kowa Company; Sanofi; GlaxoSmithKline; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Canagliflozin; Internal medicine; Post-hoc analysis; Hazard ratio; Empagliflozin; Myocardial infarction; Diabetes mellitus; Type 2 diabetes; Unstable angina; Albuminuria; Renal function; Cardiology; Endocrinology; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01011565,0.002167269,0.004893129,0.0004363545,0.0004464207,0.001643561,0.001067345,0.001338019,0.00476369],"category_scores_gemma":[0.01014735,0.0005163586,0.006641544,0.0005010061,0.001026667,0.001366135,0.0007593076,0.002320125,0.0004268299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006616829,"about_ca_system_score_gemma":0.001037322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001200523,"about_ca_topic_score_gemma":0.001869744,"domain_scores_codex":[0.9949909,0.003456238,0.0002475586,0.0004999223,0.000386696,0.0004187805],"domain_scores_gemma":[0.9909973,0.005350752,0.001082879,0.001262117,0.0004765838,0.0008303799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9710806,0.001355849,0.008582112,0.0004248091,0.008823222,0.00008618734,0.00004435808,0.001068127,0.0006395396,0.0001415136,0.001531205,0.006222464],"study_design_scores_gemma":[0.6836788,0.1476744,0.1133111,0.0001510648,0.03807885,0.0002525153,0.0001574345,0.008565644,0.002181768,0.0008578871,0.004912259,0.0001783623],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901394,0.003924421,0.0005676734,0.0004273815,0.0005411617,0.0005267693,0.00178245,0.0000581003,0.002032585],"genre_scores_gemma":[0.9932198,0.00064511,0.0005831678,0.0004195471,0.0007692311,0.0004910381,0.002527187,0.00002559286,0.001319352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01011565,"threshold_uncertainty_score":0.05349731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002848841637664525,"score_gpt":0.2135868934274806,"score_spread":0.2107380517898161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}