{"id":"W4289878771","doi":"10.1093/noajnl/vdac078.084","title":"SYST-05 OPTIMIZING HER2-TARGETED THERAPIES (TT) FOR BREAST CANCER (BC) LEPTOMENINGEAL METASTASES (LM): A SYSTEMATIC REVIEW AND META-ANALYSIS","year":2022,"lang":"en","type":"review","venue":"Neuro-Oncology Advances","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; McGill University; McGill University Health Centre; Université de Montréal","funders":"","keywords":"Medicine; Trastuzumab; Lapatinib; Trastuzumab emtansine; Hazard ratio; Internal medicine; Oncology; Confidence interval; Metastatic breast cancer; Breast cancer; Meta-analysis; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008948408,0.001080011,0.01621817,0.0006520954,0.000365605,0.00003525376,0.0003719204,0.0002567157,0.005181385],"category_scores_gemma":[0.0001682012,0.000707718,0.003760673,0.001250249,0.0002449035,0.0001895548,0.0001656215,0.0006914166,0.000007077155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005543585,"about_ca_system_score_gemma":0.0006380326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007840175,"about_ca_topic_score_gemma":0.0001412387,"domain_scores_codex":[0.9941375,0.001865425,0.0016871,0.001263687,0.000381387,0.0006648644],"domain_scores_gemma":[0.9940167,0.003095807,0.001850786,0.0006261053,0.0001661071,0.0002444695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0001227768,0.0002741902,0.000003240809,0.698275,0.2732625,0.0001936997,0.00009918225,0.00001726743,0.000002881878,0.00002021821,0.001551347,0.0261777],"study_design_scores_gemma":[0.0005262316,0.0005208104,4.209235e-7,0.003070947,0.5306525,0.0005777694,0.00004545373,0.000004082025,0.000001132194,0.000003898776,0.464321,0.0002757631],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000001162028,0.9856014,0.00003121061,0.001881766,0.0004813686,0.009047889,0.002721184,0.0001291834,0.0001048108],"genre_scores_gemma":[0.000009391967,0.9682915,0.0008808305,0.003374525,0.0001704097,0.02591527,0.0005072923,0.0001215481,0.0007292336],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6952041,"threshold_uncertainty_score":0.9995374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1045455795204107,"score_gpt":0.4351710202606059,"score_spread":0.3306254407401952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}