{"id":"W4289878771","doi":"10.1093/noajnl/vdac078.084","title":"SYST-05 OPTIMIZING HER2-TARGETED THERAPIES (TT) FOR BREAST CANCER (BC) LEPTOMENINGEAL METASTASES (LM): A SYSTEMATIC REVIEW AND META-ANALYSIS","year":2022,"lang":"en","type":"review","venue":"Neuro-Oncology Advances","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; McGill University; McGill University Health Centre; Université de Montréal","funders":"","keywords":"Medicine; Trastuzumab; Lapatinib; Trastuzumab emtansine; Hazard ratio; Internal medicine; Oncology; Confidence interval; Metastatic breast cancer; Breast cancer; Meta-analysis; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008389898,0.002371206,0.01883904,0.00715225,0.0005348901,0.003070513,0.002035512,0.001928042,0.01000239],"category_scores_gemma":[0.01685635,0.00117961,0.0326832,0.008471538,0.0005366205,0.001582044,0.00152742,0.001638023,0.0008289867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002254308,"about_ca_system_score_gemma":0.003716993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006139398,"about_ca_topic_score_gemma":0.01448031,"domain_scores_codex":[0.993768,0.003150402,0.001530877,0.000641104,0.0006905593,0.0002192161],"domain_scores_gemma":[0.9921774,0.005304729,0.001406777,0.0002565335,0.0006945084,0.0001600545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001320322,0.00001849208,0.00185347,0.5434883,0.4433517,0.00008393437,0.00006325604,0.0005553158,0.0002655254,0.0002339069,0.001160405,0.007605388],"study_design_scores_gemma":[0.001128781,0.0001816378,0.002552619,0.02728639,0.9647161,0.00008037352,0.00003460424,0.0003216858,0.0001009815,0.0003209687,0.003246839,0.00002893397],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007234694,0.9820244,0.002042221,0.0004815261,0.0002703343,0.001209154,0.005738486,0.0001479864,0.0008511227],"genre_scores_gemma":[0.23863,0.7381794,0.008000186,0.001730394,0.0003677012,0.006402838,0.004859276,0.0001260794,0.001703991],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01883904,"threshold_uncertainty_score":0.04437059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1045455795204107,"score_gpt":0.4351710202606059,"score_spread":0.3306254407401952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}