{"id":"W4289878828","doi":"10.1093/noajnl/vdac078.058","title":"LOCL-16 IMPACT OF MGMT PROMOTER METHYLATION STATUS ON TUMOR DYNAMICS DURING WEEKLY ADAPTIVE RADIOTHERAPY FOR GLIOBLASTOMA","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Temozolomide; Nuclear medicine; Fluid-attenuated inversion recovery; Glioblastoma; Medicine; Radiation therapy; Methylation; Chemoradiotherapy; O-6-methylguanine-DNA methyltransferase; Methyltransferase; Magnetic resonance imaging; Internal medicine; Cancer research; Radiology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001177977,0.0002126439,0.0004960513,0.000239361,0.0001773293,0.000005488066,0.00007981781,0.00004626041,0.0001601279],"category_scores_gemma":[0.00009657886,0.0001726187,0.0002309497,0.0002371725,0.00008291125,0.0001124437,0.00003517805,0.0002064924,0.000002070578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001449711,"about_ca_system_score_gemma":0.0001854906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002935921,"about_ca_topic_score_gemma":0.00007548233,"domain_scores_codex":[0.9985758,0.000152862,0.0003087151,0.0003792382,0.0002271291,0.0003562276],"domain_scores_gemma":[0.9987251,0.0005466788,0.0003043774,0.0002221498,0.00009580254,0.0001059368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06799458,0.01093474,0.2041275,0.0003522639,0.001955711,0.001570933,0.001930067,0.04639349,0.4740105,0.001830606,0.00133479,0.1875649],"study_design_scores_gemma":[0.05328842,0.2772988,0.2687123,0.0001629035,0.0009241069,0.001389021,0.002122462,0.02608076,0.3268746,0.002364452,0.03969967,0.001082514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957848,0.001015146,0.0002479464,0.0007054158,0.0003214053,0.001400958,0.0002244931,0.00004934905,0.000250445],"genre_scores_gemma":[0.9976014,0.0001623973,0.001208581,0.000234046,0.00008701212,0.0005929465,0.00004289995,0.00004121161,0.00002944384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2663641,"threshold_uncertainty_score":0.7039189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297588362727388,"score_gpt":0.3193062325067803,"score_spread":0.3063303488795064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}