{"id":"W4289878828","doi":"10.1093/noajnl/vdac078.058","title":"LOCL-16 IMPACT OF MGMT PROMOTER METHYLATION STATUS ON TUMOR DYNAMICS DURING WEEKLY ADAPTIVE RADIOTHERAPY FOR GLIOBLASTOMA","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Temozolomide; Nuclear medicine; Fluid-attenuated inversion recovery; Glioblastoma; Medicine; Radiation therapy; Methylation; Chemoradiotherapy; O-6-methylguanine-DNA methyltransferase; Methyltransferase; Magnetic resonance imaging; Internal medicine; Cancer research; Radiology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006226977,0.0001855478,0.0003455173,0.0001717863,0.00007301026,0.0002509544,0.0002099984,0.0001137325,0.0009298283],"category_scores_gemma":[0.0009883333,0.00009465269,0.0003041545,0.0001567206,0.000182356,0.0001525714,0.0001674262,0.0002198054,0.0001149712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005333984,"about_ca_system_score_gemma":0.0004543694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002852742,"about_ca_topic_score_gemma":0.003558118,"domain_scores_codex":[0.9997148,0.000112657,0.00001559716,0.00005914742,0.0000545949,0.000043221],"domain_scores_gemma":[0.9996694,0.000117985,0.0001125851,0.00003320552,0.0000226173,0.00004412445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.08258653,0.001889675,0.3821548,0.0002991646,0.0009568356,0.0002991263,0.0003723025,0.02302932,0.3176597,0.0002959664,0.000652898,0.1898039],"study_design_scores_gemma":[0.0005007694,0.03035455,0.8720179,0.00001730384,0.0006236979,0.0002505178,0.0001519396,0.03322917,0.06126346,0.0002976641,0.001258373,0.00003469441],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992175,0.0001383302,0.0004111211,0.00001377898,0.000003389996,0.00001274515,0.00007084633,0.00001286379,0.0001194968],"genre_scores_gemma":[0.99961,0.00002281467,0.0001678924,0.000004409875,0.000001491353,0.00001183112,0.00005549883,0.000005136242,0.0001208632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002852742,"threshold_uncertainty_score":0.005672276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297588362727388,"score_gpt":0.3193062325067803,"score_spread":0.3063303488795064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}