{"id":"W4289884109","doi":"10.26434/chemrxiv-2022-w8xz2","title":"Mechanistic Evidence for a Radical-Radical Recombination Pathway of Flavin-based Photocatalytic Tyrosine Labeling","year":2022,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"bioluminescence and chemiluminescence research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Radical; Chemistry; Photochemistry; Flavin group; Tyrosine; Radical ion; Phenol; Radical cyclization; Covalent bond; Stereochemistry; Organic chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008492193,0.0003444662,0.0004481741,0.0001100239,0.0001284374,0.0000356299,0.0008621119,0.000529014,0.0001286124],"category_scores_gemma":[0.001470277,0.0003606264,0.0003450251,0.0002400449,0.0002867891,0.000005547955,0.0006037668,0.0004845002,0.000003585239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001150418,"about_ca_system_score_gemma":0.0009798721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003738219,"about_ca_topic_score_gemma":0.000005787908,"domain_scores_codex":[0.9975285,0.00007441694,0.0005415411,0.0009375003,0.000460183,0.0004578461],"domain_scores_gemma":[0.9981426,0.0001555583,0.0003168756,0.0008951297,0.0003285474,0.0001612872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003016974,0.0002645357,0.0003691074,0.001623384,0.00005438695,0.000004194661,0.00001761191,0.00004497482,0.9953232,0.00006530879,0.0009395048,0.0009920738],"study_design_scores_gemma":[0.0007506442,0.0003772074,0.00003472665,0.0005537469,0.00006858642,0.000003642633,0.00003477966,0.003761883,0.9912066,0.0003185287,0.002499767,0.0003898675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740591,0.005827838,0.01527567,0.001035086,0.0007142295,0.002710709,0.0001420719,0.00006342198,0.0001718622],"genre_scores_gemma":[0.9934278,0.0004821952,0.00224199,0.00013114,0.0002767644,0.0009319765,0.001961009,0.00006538475,0.0004817873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01936864,"threshold_uncertainty_score":0.9998845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05936113592085746,"score_gpt":0.3377834273657607,"score_spread":0.2784222914449033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}