{"id":"W4289886692","doi":"10.1038/s41467-022-32335-8","title":"Afadin couples RAS GTPases to the polarity rheostat Scribble","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Canadian Institutes of Health Research; Cancer Research Society; Genome Canada","keywords":"PDZ domain; Cell biology; GTPase; Effector; Cell polarity; CDC42; Biology; Motility; Polarity (international relations); Scaffold protein; Signal transduction; Chemistry; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001293576,0.0002595593,0.0001491138,0.0002488213,0.0003042203,0.0004382486,0.0002336913,0.0002709138,0.002115166],"category_scores_gemma":[0.0001671917,0.0002260415,0.0001865211,0.0001125649,0.0002661519,0.0002607183,0.0004794823,0.0005509681,0.001002696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006787724,"about_ca_system_score_gemma":0.0002230494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006070947,"about_ca_topic_score_gemma":0.001175748,"domain_scores_codex":[0.9998001,0.00002702606,0.00001003475,0.00006113683,0.00006779684,0.00003391102],"domain_scores_gemma":[0.9998928,0.00001193758,0.00003085105,0.00001325061,0.00001105674,0.0000399757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003390029,0.000004840063,0.0001125152,0.000007723019,0.00000108468,0.00003426083,0.000004886987,0.00004068924,0.9993382,0.0001005324,0.00001678205,0.0003045294],"study_design_scores_gemma":[0.00001183175,0.00003740879,0.004052458,0.000002386602,0.000002668385,0.0003251647,0.00002276787,0.001674095,0.9909213,0.0001152575,0.002831304,0.000003440183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918502,0.0004027311,0.004873718,0.0001338343,0.00002734435,0.0000173609,0.0002290628,0.00008002236,0.002385707],"genre_scores_gemma":[0.9931965,0.0002141782,0.002584889,0.00005915739,0.000004934271,0.00001110871,0.0003362547,0.00003221703,0.003560664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002115166,"threshold_uncertainty_score":0.007075906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641862672143965,"score_gpt":0.2926529224831389,"score_spread":0.2762342957616992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}