{"id":"W4289886692","doi":"10.1038/s41467-022-32335-8","title":"Afadin couples RAS GTPases to the polarity rheostat Scribble","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Canadian Institutes of Health Research; Cancer Research Society; Genome Canada","keywords":"PDZ domain; Cell biology; GTPase; Effector; Cell polarity; CDC42; Biology; Motility; Polarity (international relations); Scaffold protein; Signal transduction; Chemistry; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000258776,0.00008518965,0.00006612052,0.00004030919,0.001098935,0.00003886096,0.00116048,0.00007610535,0.0001385079],"category_scores_gemma":[0.0001693605,0.00007423962,0.00008270596,0.000214684,0.00003506516,0.000003272778,0.001286603,0.0006383882,0.0000210185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003344239,"about_ca_system_score_gemma":0.00007051977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009347179,"about_ca_topic_score_gemma":0.00127402,"domain_scores_codex":[0.9992862,0.0001491171,0.0001239351,0.0001724129,0.000128502,0.0001397986],"domain_scores_gemma":[0.9980677,0.00004735705,0.00004868846,0.001686078,0.00009725516,0.00005295802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005468286,0.0004181451,0.0007607622,0.000003442869,0.0001117227,0.000001057356,0.0002653485,0.0002645233,0.577425,0.05792809,0.3608387,0.001928612],"study_design_scores_gemma":[0.00008769065,0.00008057898,0.0003598526,0.000001881187,0.00001420522,0.00001604232,0.0003788057,0.0003532632,0.01135112,0.0001251156,0.9871351,0.00009630369],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5541212,0.1374109,0.008461424,0.2590795,0.004506275,0.003164093,0.003302881,0.0002176544,0.02973606],"genre_scores_gemma":[0.9920455,0.0005695708,0.001015825,0.003724076,0.00007282083,0.000153789,0.0008465338,0.00001558237,0.001556364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6262965,"threshold_uncertainty_score":0.8452234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641862672143965,"score_gpt":0.2926529224831389,"score_spread":0.2762342957616992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}