{"id":"W4289928095","doi":"10.1016/j.annemergmed.2022.05.032","title":"A Neuropharmacological Model to Explain Buprenorphine Induction Challenges","year":2022,"lang":"en","type":"review","venue":"Annals of Emergency Medicine","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Buprenorphine; Medicine; Agonist; Dosing; Pharmacology; Fentanyl; Opioid; Methadone; Opioid use disorder; Anesthesia; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005804509,0.001010867,0.0008869646,0.001902511,0.0002565589,0.0011061,0.001059096,0.001511984,0.004448602],"category_scores_gemma":[0.00110603,0.0001842074,0.0007324454,0.001108182,0.0007493233,0.001431837,0.000674899,0.001801569,0.001562518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007387165,"about_ca_system_score_gemma":0.001519884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001243048,"about_ca_topic_score_gemma":0.001963129,"domain_scores_codex":[0.9998424,0.00003771406,0.00002681381,0.0000278215,0.00004900449,0.0000162543],"domain_scores_gemma":[0.9997416,0.0001420515,0.0000437294,0.000008076761,0.00005257611,0.00001193447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001845866,0.0001982463,0.0005321235,0.03722189,0.0002863592,0.0006988198,0.0001846453,0.0009192863,0.002985371,0.04516994,0.04466543,0.8669532],"study_design_scores_gemma":[0.0001222932,0.000282167,0.001593586,0.01637476,0.0006328652,0.002931811,0.0002198817,0.000978457,0.001432147,0.02193522,0.9534448,0.00005189947],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003530016,0.9933404,0.0008715702,0.00188243,0.000580936,0.00001969649,0.00004942516,0.00001857301,0.002883882],"genre_scores_gemma":[0.004121662,0.9919012,0.0007995996,0.001141324,0.0005014845,0.00002752708,0.00004798314,0.00000307115,0.001456057],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004448602,"threshold_uncertainty_score":0.01488203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5275235409721027,"score_gpt":0.4953317059188472,"score_spread":0.03219183505325557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}