{"id":"W4289938927","doi":"10.1016/j.mam.2022.101111","title":"CD33 isoforms in microglia and Alzheimer's disease: Friend and foe","year":2022,"lang":"en","type":"review","venue":"Molecular Aspects of Medicine","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Institute of Aging; Canadian Glycomics Network; Canadian Institutes of Health Research; Alzheimer Society; Weston Brain Institute","keywords":"Microglia; TREM2; SIGLEC; CD33; Neuroscience; Disease; Receptor; Alzheimer's disease; Dementia; Pathogenesis; Gene isoform; Biology; Immunology; Medicine; Inflammation; Gene; Cell biology; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001203445,0.001300703,0.001860916,0.002030276,0.000461482,0.001957139,0.001266189,0.002591859,0.002573529],"category_scores_gemma":[0.0009464438,0.000339202,0.0005605186,0.00230776,0.001106189,0.003033148,0.00102571,0.003525611,0.001951358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008203936,"about_ca_system_score_gemma":0.001260456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00154364,"about_ca_topic_score_gemma":0.002856556,"domain_scores_codex":[0.9997968,0.0000396656,0.00002783674,0.00003962817,0.00006946245,0.00002652686],"domain_scores_gemma":[0.9995608,0.0001721027,0.00005036192,0.00001538855,0.0001347666,0.00006657658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000246073,0.00009975955,0.0002681145,0.01072801,0.0001082944,0.0005376015,0.0001069287,0.0003774175,0.002134545,0.006482459,0.09048606,0.8884248],"study_design_scores_gemma":[0.00004534207,0.0001007969,0.0007130565,0.003181724,0.0001111209,0.00136542,0.00009714983,0.0001108405,0.0003078316,0.004192876,0.9897493,0.00002459771],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003979126,0.9989539,0.00004437314,0.0004525328,0.0002639861,0.000001165242,0.000005660537,0.000002489021,0.0002360602],"genre_scores_gemma":[0.0004411787,0.9978683,0.0001140292,0.0004124818,0.0006796691,0.000003440569,0.00001205593,7.964184e-7,0.0004680106],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002591859,"threshold_uncertainty_score":0.008609295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05369558643144073,"score_gpt":0.3173008196994138,"score_spread":0.263605233267973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}