{"id":"W4289946720","doi":"10.1021/acscatal.2c01956","title":"Active-Site Engineering Switches Carbohydrate Regiospecificity in a Fungal Copper Radical Oxidase","year":2022,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Photosynthetic Processes and Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Genome British Columbia; Genome Canada","keywords":"Copper; Chemistry; Active site; Glucose oxidase; Catalysis; Carbohydrate; Biochemistry; Combinatorial chemistry; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796847,0.0002151319,0.0001359067,0.00008231492,0.0001124162,0.0002528874,0.0002896589,0.0001837688,0.0006133228],"category_scores_gemma":[0.0001985351,0.0001024297,0.0001669994,0.0001054266,0.0001805947,0.0001249282,0.0001938618,0.0004135845,0.0002136314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002553283,"about_ca_system_score_gemma":0.0001866455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007897835,"about_ca_topic_score_gemma":0.0009466435,"domain_scores_codex":[0.9999065,0.00001616248,0.00001080278,0.0000206592,0.0000212558,0.00002453533],"domain_scores_gemma":[0.9998869,0.00002232581,0.00003792967,0.00001610731,0.00001168689,0.00002506288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000862069,0.00002917236,0.0001096778,0.00001864693,0.000004657786,0.00005834736,0.00002106798,0.0001528476,0.9971921,0.0002858053,0.0000178696,0.002023709],"study_design_scores_gemma":[0.00001165122,0.0001010462,0.0004914908,0.000003046716,0.000007610172,0.00009471804,0.000009720933,0.0008643257,0.9970959,0.00006297205,0.00125167,0.000005829505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952102,0.00009521998,0.004031321,0.00003522756,0.00001380954,0.00001431184,0.00004279325,0.00007364622,0.0004834632],"genre_scores_gemma":[0.9969407,0.0000787025,0.002180497,0.00001385337,0.000003479233,0.00000568255,0.00006199041,0.00002879931,0.0006863526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007897835,"threshold_uncertainty_score":0.002051771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006442459501461597,"score_gpt":0.2012476445026804,"score_spread":0.1948051850012188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}