{"id":"W4289948950","doi":"10.1016/j.nicl.2022.103144","title":"Detection of emerging neurodegeneration using Bayesian linear mixed-effect modeling","year":2022,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Research and Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; School of Public Health, University of California Berkeley; Allergan; National Institute of Neurological Disorders and Stroke; IXICO; Servier; H. Lundbeck A/S; Deutsches Zentrum für Neurodegenerative Erkrankungen; Eisai; Korea Health Industry Development Institute; Voyager Therapeutics; Northern California Institute for Research and Education; Japan Agency for Medical Research and Development; Pfizer; Biogen; BioClinica; Weill Institute for Neurosciences, University of California, San Francisco; Fleni; Takeda Pharmaceuticals U.S.A.; AbbVie; Johnson and Johnson; Verily Life Sciences; Meso Scale Diagnostics; Teva Pharmaceutical Industries; University of Southern California; Celgene; Merck; GlaxoSmithKline; Novartis Pharmaceuticals Corporation; National Institutes of Health; Association for Frontotemporal Degeneration; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Sanofi; Fujirebio US; Alzheimer's Association; F. Hoffmann-La Roche; Genentech; Larry L. Hillblom Foundation; HDL Therapeutics; Michael J. Fox Foundation for Parkinson's Research","keywords":"Neurodegeneration; Bayesian probability; Computer science; Artificial intelligence; Medicine; Disease; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01253958,0.00177639,0.002211799,0.003054784,0.000929466,0.002622996,0.003703852,0.002784139,0.002889129],"category_scores_gemma":[0.02495331,0.001589117,0.004254545,0.002102617,0.001495661,0.001598655,0.001974739,0.003481607,0.0006196393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001870599,"about_ca_system_score_gemma":0.001772944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02635571,"about_ca_topic_score_gemma":0.03108261,"domain_scores_codex":[0.9953421,0.002841472,0.000221676,0.00100714,0.0003617275,0.0002259083],"domain_scores_gemma":[0.9820186,0.01532262,0.001034823,0.0006761344,0.0007075891,0.0002402903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0006451923,0.0002316454,0.02782624,0.000337088,0.001710582,0.0006510751,0.0003600676,0.8725911,0.001707972,0.03679368,0.002904613,0.05424064],"study_design_scores_gemma":[0.00005997521,0.00005774115,0.00222512,0.00003301357,0.0001329719,0.00008307957,0.00002144153,0.970149,0.0002522261,0.0258668,0.001075206,0.00004334415],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.04062373,0.001283759,0.9539034,0.0008064547,0.00008819209,0.0002253665,0.001346327,0.0009059604,0.0008168143],"genre_scores_gemma":[0.595108,0.00153698,0.3931355,0.0007121049,0.000230607,0.001242279,0.003552442,0.0002621178,0.004219971],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02635571,"threshold_uncertainty_score":0.06631643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1211320420378094,"score_gpt":0.3678882573026831,"score_spread":0.2467562152648737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}