{"id":"W4289986017","doi":"10.3390/curroncol29080437","title":"The Effect of Tobacco Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch Repair Mechanism and miRNA Markers, in Hypopharyngeal Squamous Cell Carcinoma: An In Vivo Model and Clinical Evidence","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences","keywords":"Carcinogenesis; Medicine; Cancer research; In vivo; DNA mismatch repair; Nicotine; microRNA; DNA damage; DNA repair; MLH1; Cancer; Internal medicine; Biology; Gene; DNA; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002019557,0.0003350168,0.0002906155,0.000299211,0.0001546163,0.0001911916,0.0001712884,0.0003078957,0.001065125],"category_scores_gemma":[0.00008406407,0.0001764733,0.0003498532,0.0001498281,0.000299278,0.0002094481,0.0002114103,0.00036648,0.0001809051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001648295,"about_ca_system_score_gemma":0.0001679962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006484403,"about_ca_topic_score_gemma":0.001565722,"domain_scores_codex":[0.9998624,0.00003015174,0.00001285828,0.00003797985,0.00003183511,0.00002466235],"domain_scores_gemma":[0.9999083,0.00001479025,0.00001926272,0.00001722467,0.00001220962,0.00002817252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004346528,0.00008737918,0.001496952,0.00002701452,0.00001180456,0.00003764208,0.00001704409,0.00001679465,0.9966815,0.000009146476,0.00000773071,0.001172394],"study_design_scores_gemma":[0.00002139629,0.004763542,0.04778812,0.000006215712,0.00007381781,0.0004742453,0.0001000551,0.0004719911,0.9451047,0.00003193948,0.001158785,0.000005341513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996736,0.001931902,0.0007106302,0.00002477211,0.00001387906,0.00002050494,0.0001108039,0.00001317334,0.0004382803],"genre_scores_gemma":[0.9946542,0.001703673,0.00102983,0.00003425935,0.00001117637,0.00004478919,0.0003279625,0.000007698646,0.002186437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001065125,"threshold_uncertainty_score":0.003563225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04905689757532252,"score_gpt":0.3550712155573569,"score_spread":0.3060143179820344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}