{"id":"W4289986017","doi":"10.3390/curroncol29080437","title":"The Effect of Tobacco Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch Repair Mechanism and miRNA Markers, in Hypopharyngeal Squamous Cell Carcinoma: An In Vivo Model and Clinical Evidence","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences","keywords":"Carcinogenesis; Medicine; Cancer research; In vivo; DNA mismatch repair; Nicotine; microRNA; DNA damage; DNA repair; MLH1; Cancer; Internal medicine; Biology; Gene; DNA; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009503815,0.0001449538,0.0002617808,0.00005268986,0.0001098213,0.00001156897,0.0001204727,0.0001123181,0.000003066177],"category_scores_gemma":[0.00009797019,0.0001186401,0.00003705317,0.00006566395,0.0001770644,0.00000761666,0.000240912,0.0002313384,5.159445e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000388293,"about_ca_system_score_gemma":0.00008273184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009799292,"about_ca_topic_score_gemma":0.0003593116,"domain_scores_codex":[0.9984269,0.0004889572,0.000335393,0.0004694491,0.00008858223,0.0001907696],"domain_scores_gemma":[0.9992427,0.0002712336,0.0001220443,0.0002608359,0.00002378979,0.00007944433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003088344,0.0006565523,0.8210691,0.0002221014,0.00002263624,0.00001461651,0.0002600283,0.0001020327,0.1234872,0.0003012775,0.001276069,0.04950009],"study_design_scores_gemma":[0.02068057,0.03640322,0.8240033,0.0001144624,0.0003086098,0.0001819324,0.001314944,0.06121936,0.03981802,0.001142802,0.01354956,0.001263267],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838247,0.01539782,0.000009723909,0.0001436465,0.0001725448,0.0003726542,0.00003078359,0.000004302316,0.00004383193],"genre_scores_gemma":[0.9960098,0.003670278,0.00006321133,0.00004809913,0.00004203564,0.000107618,0.00001309493,0.00001129308,0.00003460071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08366914,"threshold_uncertainty_score":0.4838004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04905689757532252,"score_gpt":0.3550712155573569,"score_spread":0.3060143179820344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}