{"id":"W4290065735","doi":"10.1002/ijc.34218","title":"A multi‐omic single cell sequencing approach to develop a <scp>CD8</scp> T cell specific gene signature for <scp>anti‐PD1</scp> response in solid tumors","year":2022,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bristol-Myers Squibb Canada","keywords":"Transcriptome; CD8; T-cell receptor; Nivolumab; Biology; Immune checkpoint; Gene signature; Immune system; T cell; Cancer research; Cytotoxic T cell; Cell; Immunotherapy; Immunology; Gene; Computational biology; Gene expression; Genetics; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003401656,0.0002402243,0.0003014512,0.0005836853,0.0002245255,0.0006055442,0.0001732697,0.0003540929,0.001053337],"category_scores_gemma":[0.000372925,0.0001520912,0.0002706794,0.0003368338,0.0002191564,0.0001866878,0.0002111267,0.0004969891,0.0003699843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002557744,"about_ca_system_score_gemma":0.0003138928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005066241,"about_ca_topic_score_gemma":0.001625529,"domain_scores_codex":[0.9997849,0.00002452731,0.000012766,0.00008166404,0.00007262408,0.00002357251],"domain_scores_gemma":[0.9997547,0.00005912344,0.00006865579,0.00003151669,0.0000595913,0.00002638904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006757348,0.00002303202,0.002468326,0.00004212524,0.00001585217,0.0000245197,0.0000206411,0.0003533066,0.9917904,0.00007511076,0.0001703107,0.00494877],"study_design_scores_gemma":[0.00002927367,0.0006496313,0.07623292,0.00002389116,0.0001254814,0.0005039861,0.0001473364,0.02813492,0.8866542,0.000649565,0.006827203,0.00002166927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9559551,0.0007595847,0.03544096,0.0001556811,0.00004393123,0.0002126799,0.004980768,0.0004915021,0.001959585],"genre_scores_gemma":[0.9487217,0.0004092575,0.04351887,0.0003583346,0.00003450049,0.0003253969,0.00409782,0.0001473079,0.002386817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001053337,"threshold_uncertainty_score":0.003523767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03204679548992201,"score_gpt":0.2975850190451819,"score_spread":0.2655382235552599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}