{"id":"W4290189482","doi":"10.1101/2022.08.05.503015","title":"Simulated colonic fluid replicates the <i>in vivo</i> growth capabilities of <i>Citrobacter rodentium cpxRA</i> mutants and uncovers additive effects of Cpx regulated genes on fitness","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University of Alberta","keywords":"Citrobacter rodentium; Regulon; Virulence; Biology; Mutant; Microbiology; Gene; Phenotype; Gene expression; Pathogen; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002233919,0.0006882122,0.0003140922,0.000244899,0.0001402696,0.000437398,0.000332409,0.0004421685,0.001105357],"category_scores_gemma":[0.0002517677,0.0001689054,0.0003217548,0.0001677853,0.0003118794,0.0002096231,0.000428252,0.0006746655,0.000232913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000301407,"about_ca_system_score_gemma":0.0002118736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001535082,"about_ca_topic_score_gemma":0.001138371,"domain_scores_codex":[0.9994876,0.000113753,0.0000616268,0.000107046,0.000121376,0.0001085522],"domain_scores_gemma":[0.9995818,0.00007537829,0.0001311209,0.00006064179,0.00004114224,0.0001099989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001839828,0.00009578671,0.0003576036,0.00001901988,0.000005183749,0.000026781,0.000009922001,0.0001036461,0.9987352,0.00003213555,0.00002138642,0.0004092161],"study_design_scores_gemma":[0.000008850272,0.0009663427,0.00438495,0.00000645238,0.00001053598,0.00009251052,0.00006928771,0.001337948,0.9926342,0.00002041203,0.0004593291,0.000009160052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977564,0.0001420942,0.0009507677,0.00006507592,0.00002046001,0.00003038073,0.0004242104,0.00006556863,0.0005450929],"genre_scores_gemma":[0.9963105,0.0001085341,0.001874608,0.00004307506,0.000004928076,0.00003853292,0.0005353661,0.00003446994,0.00105009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001535082,"threshold_uncertainty_score":0.003697813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005775884775715575,"score_gpt":0.2182801191159762,"score_spread":0.2125042343402606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}