{"id":"W4290466437","doi":"10.3390/cancers14153810","title":"Cancer-Associated Fibroblasts in a 3D Engineered Tissue Model Induce Tumor-like Matrix Stiffening and EMT Transition","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Extracellular matrix; Urothelium; Stroma; Epithelial–mesenchymal transition; Tumor microenvironment; Fibroblast; Cell biology; Chemistry; Cancer-Associated Fibroblasts; Tissue engineering; Cancer research; Pathology; Biology; Biomedical engineering; Downregulation and upregulation; Anatomy; Immunohistochemistry; Medicine; Tumor cells; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007217732,0.00009653517,0.00009991533,0.00005502101,0.00009328223,0.00001174832,0.00006662811,0.00004504366,0.00005393056],"category_scores_gemma":[0.00001024182,0.000119575,0.00003416539,0.0001154978,0.00001059402,0.000005043972,0.00004811588,0.0001510953,3.65558e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003698548,"about_ca_system_score_gemma":0.0002151669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006696157,"about_ca_topic_score_gemma":0.0005546745,"domain_scores_codex":[0.9993682,0.00002972552,0.0001217352,0.0002300179,0.00008243959,0.0001679088],"domain_scores_gemma":[0.9997811,0.000004301958,0.00004608696,0.00009811376,0.00002369458,0.00004668389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00004808072,0.00001149704,0.000009395798,0.000008067211,0.00002975167,0.000004894833,0.0002771661,0.2163073,0.7814125,0.00001400215,0.0006862137,0.001191137],"study_design_scores_gemma":[0.001853796,0.0004891203,0.0001571586,0.00006979446,0.00005973957,0.000029708,0.0006566752,0.7855545,0.193239,0.0001021503,0.0172458,0.0005426048],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995898,0.001500966,0.001908537,0.0000815578,0.0002293351,0.0001398585,0.0001444448,0.0000112069,0.00008609332],"genre_scores_gemma":[0.9988764,0.0001413717,0.0001467823,0.0001771638,0.00004062023,0.0001213937,0.0001574052,0.00001979624,0.0003190561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5881735,"threshold_uncertainty_score":0.4876127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008575440648101458,"score_gpt":0.2484354180351622,"score_spread":0.2398599773870608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}