{"id":"W4290467448","doi":"10.3390/cancers14153808","title":"Neither Tumor-Infiltrating Lymphocytes nor Cytotoxic T Cells Predict Enhanced Benefit from Chemotherapy in the DBCG77B Phase III Clinical Trial","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Region Hovedstaden; Canadian Cancer Society","keywords":"Medicine; Oncology; Cyclophosphamide; Breast cancer; Chemotherapy; Immune system; Tissue microarray; Hazard ratio; Internal medicine; Cytotoxic T cell; FOXP3; CD8; Tumor-infiltrating lymphocytes; Biomarker; Cancer; Immunology; Biology; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005051943,0.0008266215,0.00183694,0.0002958581,0.0002670904,0.0009097673,0.0005154421,0.0007842738,0.002074055],"category_scores_gemma":[0.002245022,0.0002383996,0.001099215,0.000312106,0.000604586,0.0005509182,0.0003262161,0.001499257,0.000400697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005063031,"about_ca_system_score_gemma":0.001216518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002538152,"about_ca_topic_score_gemma":0.0008936551,"domain_scores_codex":[0.9985564,0.0009148925,0.00008997507,0.0001259098,0.0001386445,0.0001741485],"domain_scores_gemma":[0.9987578,0.0005434366,0.0002212258,0.0001230403,0.00005474672,0.0002997052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9140626,0.004055192,0.0208078,0.0005202643,0.00194252,0.0001051007,0.00007862962,0.002141536,0.01782883,0.0002286059,0.001161968,0.03706711],"study_design_scores_gemma":[0.4928495,0.3356799,0.1302681,0.0002418121,0.006550821,0.0004916268,0.00009030304,0.006344419,0.01735054,0.001245032,0.008806678,0.00008130992],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923699,0.003079338,0.0005722306,0.0003390695,0.00007206319,0.0008463119,0.000811404,0.00002951286,0.001880085],"genre_scores_gemma":[0.9940807,0.0008362503,0.0009578994,0.0004293189,0.00008426584,0.00113083,0.001475241,0.00001864062,0.0009868917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005051943,"threshold_uncertainty_score":0.02671754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03410743516031906,"score_gpt":0.3392639275326478,"score_spread":0.3051564923723287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}