{"id":"W4290612352","doi":"10.3389/fpubh.2022.945448","title":"SARS-CoV-2 pre-exposure prophylaxis: A potential COVID-19 preventive strategy for high-risk populations, including healthcare workers, immunodeficient individuals, and poor vaccine responders","year":2022,"lang":"en","type":"review","venue":"Frontiers in Public Health","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"McGill University; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Medicine; Pandemic; Pre-exposure prophylaxis; Coronavirus disease 2019 (COVID-19); Intensive care medicine; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Health care; Vaccination; Disease; Immunology; Virology; Human immunodeficiency virus (HIV); Infectious disease (medical specialty); Internal medicine; Men who have sex with men","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005644632,0.000361654,0.0005963694,0.000542362,0.0001787218,0.0006786072,0.00032874,0.0008269406,0.002421884],"category_scores_gemma":[0.0010664,0.0000980605,0.0005972038,0.0002247718,0.0002246112,0.0007305086,0.0004157521,0.001369101,0.0005773266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002736956,"about_ca_system_score_gemma":0.0009510471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000663141,"about_ca_topic_score_gemma":0.001148487,"domain_scores_codex":[0.9997706,0.00008399976,0.00004032017,0.0000257354,0.00004794289,0.00003154353],"domain_scores_gemma":[0.999627,0.0001697956,0.00008860232,0.000008416188,0.00007019001,0.00003597541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004654371,0.0001803951,0.004841527,0.01191903,0.0002258363,0.001719499,0.0003630417,0.000482231,0.00562454,0.004624027,0.03666012,0.9328944],"study_design_scores_gemma":[0.00009091086,0.001616567,0.01788072,0.01117543,0.0008077128,0.01186921,0.0007578506,0.0005440837,0.003092939,0.003767092,0.948334,0.00006348774],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005551122,0.9806139,0.001436832,0.007812601,0.0009956179,0.00004639523,0.00009992043,0.00004184075,0.003401753],"genre_scores_gemma":[0.0253888,0.9640623,0.002087166,0.003782093,0.002168369,0.00006667573,0.0002018612,0.00001257856,0.002230139],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002421884,"threshold_uncertainty_score":0.008102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2254939079410388,"score_gpt":0.4909089848721653,"score_spread":0.2654150769311265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}