{"id":"W4290643359","doi":"10.1084/jem.20212311","title":"Helminth-induced reprogramming of the stem cell compartment inhibits type 2 immunity","year":2022,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institute of Infection and Immunity; Université de Montréal; Montreal Clinical Research Institute; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Heligmosomoides polygyrus; Biology; Stem cell; Cell biology; Intestinal epithelium; Reprogramming; Cellular differentiation; Immunology; Cytokine; Organoid; Cell type; Epithelium; Immune system; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001024714,0.00009321635,0.0002434607,0.00006560476,0.0004565485,0.000001991691,0.0004288677,0.00002786179,0.0007401431],"category_scores_gemma":[0.00002754874,0.00004745218,0.00008505516,0.0002148788,0.0001322405,0.00003011019,0.0002747134,0.0004539198,0.000005409857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009492556,"about_ca_system_score_gemma":0.00006681692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009285017,"about_ca_topic_score_gemma":0.000001189736,"domain_scores_codex":[0.9984474,0.0007848172,0.0004612032,0.00005573425,0.0001108904,0.0001399794],"domain_scores_gemma":[0.9988741,0.0002103701,0.0005262704,0.0002889701,0.00008659527,0.00001367036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007230116,0.0003111083,0.0001105983,0.000003482444,0.00008614569,0.000001521396,0.00575102,0.00001054931,0.9903514,0.0001009171,0.001562151,0.0009881124],"study_design_scores_gemma":[0.001792944,0.002274849,0.001068312,0.00004315553,0.00006888103,0.00043111,0.03736934,0.000001814376,0.9469481,0.000008431145,0.00994458,0.0000484797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739504,0.02302051,0.000003702406,0.0009919383,0.00143386,0.0001853241,0.000002235203,0.000004415924,0.0004076221],"genre_scores_gemma":[0.9986858,0.00005299076,0.000006051451,0.0001225472,0.00003199901,0.000004174229,0.000002785827,0.00000788105,0.001085732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04340328,"threshold_uncertainty_score":0.8104047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0350436461237589,"score_gpt":0.2987186135661587,"score_spread":0.2636749674423998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}