{"id":"W4290643359","doi":"10.1084/jem.20212311","title":"Helminth-induced reprogramming of the stem cell compartment inhibits type 2 immunity","year":2022,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institute of Infection and Immunity; Université de Montréal; Montreal Clinical Research Institute; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Heligmosomoides polygyrus; Biology; Stem cell; Cell biology; Intestinal epithelium; Reprogramming; Cellular differentiation; Immunology; Cytokine; Organoid; Cell type; Epithelium; Immune system; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009035127,0.0001986542,0.0001651917,0.0001575907,0.00007388935,0.000235337,0.00008618825,0.0001562263,0.001281265],"category_scores_gemma":[0.00006656013,0.0000836856,0.0001063936,0.00007794124,0.0002086926,0.0001015035,0.0001588745,0.0004496136,0.0002387251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009570926,"about_ca_system_score_gemma":0.0001203121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001685841,"about_ca_topic_score_gemma":0.0005469405,"domain_scores_codex":[0.9998811,0.00002173801,0.000009361047,0.00002291213,0.00002393739,0.00004078261],"domain_scores_gemma":[0.9999063,0.00001973716,0.00003130165,0.00001527151,0.000005271123,0.00002204363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006642694,0.00002076537,0.0001934171,0.00001600894,0.000001791597,0.00002578841,0.00001237023,0.00002708945,0.9985323,0.00006881692,0.00001862569,0.001016596],"study_design_scores_gemma":[0.00001445631,0.0004963563,0.005331508,0.000005184818,0.000008499246,0.0001317601,0.00003654199,0.0003861471,0.9915316,0.00003718718,0.002018701,0.000002090284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976742,0.0004009426,0.0006300664,0.00002873844,0.00001400429,0.00001249752,0.0001198704,0.0000540288,0.001065588],"genre_scores_gemma":[0.9970717,0.0002485921,0.0004691292,0.00002646869,0.000005453233,0.00001434912,0.000159188,0.00001275696,0.001992304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001281265,"threshold_uncertainty_score":0.00428623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0350436461237589,"score_gpt":0.2987186135661587,"score_spread":0.2636749674423998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}