{"id":"W4290660012","doi":"10.1038/s41467-022-32386-x","title":"Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Daiichi Sankyo Europe; Moonshot Research and Development Program; Instituto de Salud Carlos III; Science and Engineering Research Board; Japan Society for the Promotion of Science; Wellcome Trust; Council of Scientific and Industrial Research, India; Department of Biotechnology, Ministry of Science and Technology, India; Ministerio de Economía y Competitividad; Indian Institute of Technology Kanpur; Government of Canada; The Wellcome Trust DBT India Alliance; Japan Science and Technology Agency; Daiichi Sankyo Foundation of Life Science; Canadian Institutes of Health Research; Uehara Memorial Foundation","keywords":"G protein-coupled receptor; Endosome; Arrestin; Phosphorylation; Allosteric regulation; Internalization; Cell biology; Effector; Biology; Receptor; Agonist; Signal transduction; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002624101,0.00007173648,0.00009419326,0.00005361706,0.0001531433,0.000009709099,0.0003163923,0.00009757798,0.00002102168],"category_scores_gemma":[0.00005838042,0.00008027987,0.00002703515,0.000133237,0.00002686725,0.000003365201,0.0002540184,0.000315284,1.52515e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001486004,"about_ca_system_score_gemma":0.00002544897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001972032,"about_ca_topic_score_gemma":0.00002748844,"domain_scores_codex":[0.9993226,0.0001594855,0.000177452,0.0001532069,0.00009380782,0.00009346708],"domain_scores_gemma":[0.9993701,0.00004308951,0.00008765792,0.0004405807,0.00003498643,0.00002359522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000132566,0.00005745276,0.0003331571,0.000004493586,0.000009427536,1.572413e-7,0.0001350947,0.0005963976,0.9957978,0.0003976504,0.00006115349,0.002593959],"study_design_scores_gemma":[0.001669744,0.0007281367,0.003870412,0.00009569598,0.00006822211,0.00005154065,0.001971438,0.04280311,0.9220209,0.0007590622,0.02517646,0.0007852849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939556,0.005093248,0.0003371371,0.0002563441,0.00005602561,0.0001415906,0.00001885792,0.000007153897,0.0001340562],"genre_scores_gemma":[0.9977479,0.0001488128,0.00175642,0.00007749213,0.00001272164,0.00003846909,0.0001950464,0.00001226708,0.0000108661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07377691,"threshold_uncertainty_score":0.3273718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01384461211907548,"score_gpt":0.2636719043591326,"score_spread":0.2498272922400571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}