{"id":"W4290660012","doi":"10.1038/s41467-022-32386-x","title":"Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Daiichi Sankyo Europe; Moonshot Research and Development Program; Instituto de Salud Carlos III; Science and Engineering Research Board; Japan Society for the Promotion of Science; Wellcome Trust; Council of Scientific and Industrial Research, India; Department of Biotechnology, Ministry of Science and Technology, India; Ministerio de Economía y Competitividad; Indian Institute of Technology Kanpur; Government of Canada; The Wellcome Trust DBT India Alliance; Japan Science and Technology Agency; Daiichi Sankyo Foundation of Life Science; Canadian Institutes of Health Research; Uehara Memorial Foundation","keywords":"G protein-coupled receptor; Endosome; Arrestin; Phosphorylation; Allosteric regulation; Internalization; Cell biology; Effector; Biology; Receptor; Agonist; Signal transduction; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001117331,0.0002637936,0.0001509753,0.00009793957,0.00008207031,0.0001732621,0.0002517221,0.0001959994,0.000960164],"category_scores_gemma":[0.00008199733,0.00008695558,0.0001573858,0.00006143199,0.0002238782,0.0001175576,0.000198848,0.0003639167,0.0002679042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002422206,"about_ca_system_score_gemma":0.0001017649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002210222,"about_ca_topic_score_gemma":0.0002034427,"domain_scores_codex":[0.9999392,0.000008874667,0.00000485358,0.00001521438,0.00001454077,0.00001728193],"domain_scores_gemma":[0.9999452,0.00000777619,0.00001897489,0.000006683541,0.000004084518,0.0000173658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003339426,0.00001448734,0.00002425132,0.000009233857,0.000001263845,0.00001271712,0.000003058137,0.00006911353,0.9995744,0.00007644627,0.00001411305,0.0001675161],"study_design_scores_gemma":[0.00002109947,0.0001491863,0.0004741939,0.000002471532,0.000003859552,0.00005878492,0.000005578863,0.001842027,0.9967349,0.00002961518,0.0006748018,0.000003435416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941784,0.0002439118,0.00398852,0.00007883761,0.00002692248,0.00002738528,0.0001053671,0.0000887581,0.001261896],"genre_scores_gemma":[0.9969035,0.0001525538,0.002090529,0.00005173523,0.000005749505,0.00002527672,0.00008702985,0.00001973167,0.0006639348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000960164,"threshold_uncertainty_score":0.003212094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01384461211907548,"score_gpt":0.2636719043591326,"score_spread":0.2498272922400571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}