{"id":"W4290673668","doi":"10.1038/s41591-022-01919-8","title":"Pepinemab antibody blockade of SEMA4D in early Huntington’s disease: a randomized, placebo-controlled, phase 2 trial","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Centre Hospitalier de l’Université de Montréal; University of British Columbia","funders":"","keywords":"Placebo; Randomized controlled trial; Medicine; Internal medicine; Clinical endpoint; Confidence interval; Adverse effect; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002187587,0.001673034,0.002146759,0.0004060721,0.0003670874,0.0008070259,0.0008054187,0.001823164,0.006705708],"category_scores_gemma":[0.00156634,0.0005216085,0.001122563,0.0002657251,0.0007827074,0.001032796,0.0003028209,0.002104707,0.0009365393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004914047,"about_ca_system_score_gemma":0.0008011494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003652552,"about_ca_topic_score_gemma":0.0009251438,"domain_scores_codex":[0.9994209,0.0003182377,0.00003025373,0.00009815137,0.00005594321,0.00007644124],"domain_scores_gemma":[0.9994503,0.0001846304,0.000117697,0.00003640932,0.00004960345,0.0001614453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9671231,0.00769432,0.0004487728,0.0008173141,0.0005354186,0.00006870025,0.00005143748,0.0002492979,0.004944515,0.0002081304,0.001319525,0.01653948],"study_design_scores_gemma":[0.9574239,0.04031729,0.0008095287,0.00002380426,0.0001392187,0.00003001824,0.000008477819,0.0002685768,0.0002739704,0.00008401298,0.0006142504,0.000006999449],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762635,0.007708832,0.001279916,0.001097701,0.0007981228,0.00743489,0.001639362,0.0002053844,0.003572287],"genre_scores_gemma":[0.9723822,0.003863625,0.002872729,0.001946876,0.0007822722,0.0118071,0.001791048,0.00003381377,0.004520334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006705708,"threshold_uncertainty_score":0.0224328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267061360462716,"score_gpt":0.3235308775835429,"score_spread":0.3108602639789158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}