{"id":"W4290730902","doi":"10.1101/2022.08.08.503162","title":"Apolipoprotein A1 and high-density lipoprotein limit low-density lipoprotein transcytosis by binding scavenger receptor B1","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Diabetes, Cardiovascular Risks, and Lipoproteins","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Toronto Metropolitan University; University of Toronto; St. Michael's Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Consortium canadien en neurodégénérescence associée au vieillissement; California HIV/AIDS Research Program","keywords":"Transcytosis; Scavenger receptor; Apolipoprotein B; Lipoprotein; Chemistry; Internalization; LDL receptor; Low-density lipoprotein; Receptor; Internal medicine; Endocrinology; Endocytosis; Biochemistry; Cholesterol; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002601438,0.0003056163,0.0002456916,0.0002216063,0.0001669031,0.0004907645,0.0002473555,0.0004871886,0.002356319],"category_scores_gemma":[0.0002913462,0.0001973359,0.0003030072,0.0000816871,0.0002287277,0.000218515,0.0002324125,0.0004615669,0.0009087495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003508722,"about_ca_system_score_gemma":0.0001997996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008173937,"about_ca_topic_score_gemma":0.0007176627,"domain_scores_codex":[0.9997429,0.0000643809,0.00001740596,0.00005011217,0.00005896042,0.00006621679],"domain_scores_gemma":[0.9997693,0.00005893459,0.00005894291,0.00002469712,0.00003872337,0.00004933259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001223471,0.00004962904,0.0002759156,0.00005047322,0.00001044142,0.00002379614,0.00001736606,0.00004253604,0.9978948,0.000207847,0.0000820118,0.001222811],"study_design_scores_gemma":[0.00003849033,0.0005087678,0.007365042,0.00001460045,0.00002214457,0.0002041261,0.00002995086,0.001897243,0.984848,0.0001507843,0.004912323,0.000008473688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830363,0.006217579,0.007413128,0.0003453568,0.000100801,0.00005126588,0.0001410306,0.0001569312,0.002537538],"genre_scores_gemma":[0.9886839,0.001270408,0.004758666,0.0001946322,0.00003099721,0.00008306739,0.0002713077,0.00002224947,0.004684834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002356319,"threshold_uncertainty_score":0.007882655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009806951714561984,"score_gpt":0.2028462834033504,"score_spread":0.1930393316887885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}