{"id":"W4290739295","doi":"10.1093/cid/ciac284","title":"Initiating Intramuscular Depot Medroxyprogesterone Acetate Increases Frequencies of Th17-like Human Immunodeficiency Virus Target Cells in the Genital Tract of Women in South Africa: A Randomized Trial","year":2022,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; South African Medical Research Council; Styrelsen för Internationellt Utvecklingssamarbete; Bill and Melinda Gates Foundation; United States Agency for International Development","keywords":"Medicine; Medroxyprogesterone acetate; Levonorgestrel; Population; Vaccine trial; Immunology; Vaginal ring; Randomized controlled trial; Physiology; Gynecology; Internal medicine; Human immunodeficiency virus (HIV); Hormone; Family planning","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001831753,0.0009797507,0.001528226,0.000300916,0.0003891834,0.000964839,0.000574666,0.001402309,0.006088755],"category_scores_gemma":[0.003780835,0.0005245811,0.001546956,0.0004252744,0.000848299,0.0006459259,0.0004661144,0.001647317,0.0003831031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006425783,"about_ca_system_score_gemma":0.001092125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001268941,"about_ca_topic_score_gemma":0.001948305,"domain_scores_codex":[0.9990752,0.0005208332,0.00007124763,0.0001372098,0.00005202813,0.0001434782],"domain_scores_gemma":[0.9981486,0.0007432618,0.0005141853,0.0001444424,0.00009770983,0.0003519106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.965831,0.004479412,0.006469732,0.001396982,0.002265639,0.0000771304,0.0001591985,0.0001415953,0.002053203,0.00006928935,0.0004868027,0.01657006],"study_design_scores_gemma":[0.903773,0.07624944,0.01441355,0.0002101934,0.003241539,0.00006792037,0.0001537874,0.0002215457,0.0005748492,0.0001709318,0.0009031494,0.00002009301],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922084,0.00418461,0.0001418449,0.0007425678,0.0002173221,0.001362781,0.0003785863,0.00002258804,0.0007414257],"genre_scores_gemma":[0.9941918,0.001598573,0.0005448526,0.0005934956,0.0001864861,0.001726281,0.0002014359,0.000006718019,0.0009503367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006088755,"threshold_uncertainty_score":0.02036893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04036118031870777,"score_gpt":0.3295579393608432,"score_spread":0.2891967590421354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}