{"id":"W4290785626","doi":"10.1093/brain/awac292","title":"Extracellular vesicles and seeding amplification: a step closer to a Parkinson’s disease blood test","year":2022,"lang":"en","type":"letter","venue":"Brain","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University Health Network; Toronto Western Hospital; Occupational Cancer Research Centre; University of Toronto","funders":"Rossy Foundation; Krembil Foundation; Edmond J. Safra Philanthropic Foundation","keywords":"Extracellular vesicles; Extracellular; Neuroscience; Disease; Seeding; Pathological; Neuron; Pathology; Biology; Psychology; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003358834,0.0004645375,0.000286874,0.0001301368,0.0002327862,0.0001400584,0.0005815547,0.0003886772,0.0002303929],"category_scores_gemma":[0.0006700885,0.0005376491,0.0001862997,0.000169017,0.0001203598,0.000006446057,0.0005581389,0.0006277564,0.00003550312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003723599,"about_ca_system_score_gemma":0.0001801185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000100502,"about_ca_topic_score_gemma":0.000004086515,"domain_scores_codex":[0.9972407,0.000193945,0.0003928338,0.001223618,0.0004184368,0.0005304441],"domain_scores_gemma":[0.9981436,0.000131781,0.0001870128,0.001101436,0.00006139645,0.0003747631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007365888,0.0001372854,0.00189834,0.000194058,0.00009098678,0.000677365,0.00005044815,0.000005822442,0.1833048,0.00004284524,0.8123816,0.001142716],"study_design_scores_gemma":[0.0004684564,0.0001971316,0.001564841,0.00004583856,0.0001766082,0.00004276774,0.00004176848,0.0000247804,0.003156482,0.00009670758,0.9935232,0.0006614451],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.2934968,0.04183492,0.001440551,0.6570557,0.0006261491,0.002492089,0.002210915,0.0001833526,0.0006595128],"genre_scores_gemma":[0.2086122,0.0005147243,0.00566519,0.7096891,0.01199643,0.001631446,0.008469558,0.0006550382,0.05276627],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1811415,"threshold_uncertainty_score":0.9997075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192775196715221,"score_gpt":0.2363263947222435,"score_spread":0.2243986427550913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}