{"id":"W4290785626","doi":"10.1093/brain/awac292","title":"Extracellular vesicles and seeding amplification: a step closer to a Parkinson’s disease blood test","year":2022,"lang":"en","type":"letter","venue":"Brain","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University Health Network; Toronto Western Hospital; Occupational Cancer Research Centre; University of Toronto","funders":"Rossy Foundation; Krembil Foundation; Edmond J. Safra Philanthropic Foundation","keywords":"Extracellular vesicles; Extracellular; Neuroscience; Disease; Seeding; Pathological; Neuron; Pathology; Biology; Psychology; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006059469,0.0009297671,0.00142415,0.0006502313,0.002310391,0.003665674,0.001760125,0.05088301,0.004957854],"category_scores_gemma":[0.02948217,0.0005575811,0.001360102,0.0004199869,0.004294281,0.004704854,0.001576761,0.04514845,0.006394344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00314467,"about_ca_system_score_gemma":0.002264552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001810659,"about_ca_topic_score_gemma":0.002865356,"domain_scores_codex":[0.9947701,0.001530812,0.0006258013,0.0006106084,0.002035765,0.0004269161],"domain_scores_gemma":[0.9820127,0.01333877,0.0005303755,0.0004535067,0.002495886,0.001168609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001243061,0.00003671564,0.0001998393,0.00009499075,0.00001772417,0.002151513,0.0001023544,0.00006007686,0.0007166955,0.004904771,0.972909,0.01868204],"study_design_scores_gemma":[0.0001622918,0.0001825913,0.000450937,0.0002488995,0.00002761787,0.002694579,0.000187117,0.0003538078,0.001105227,0.01790758,0.9766113,0.00006805327],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.0003221249,0.006241877,0.0004825922,0.9469605,0.04410361,0.0000146747,0.00004217717,0.00005516096,0.001777249],"genre_scores_gemma":[0.004447927,0.004174092,0.0006382165,0.8684593,0.1166025,0.00004504836,0.00003224968,0.00004535123,0.005555354],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.05088301,"threshold_uncertainty_score":0.0320459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192775196715221,"score_gpt":0.2363263947222435,"score_spread":0.2243986427550913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}