{"id":"W4290786383","doi":"10.1016/j.scr.2022.102891","title":"Generation of new human iPSC cell line (UOMi008-A) from a Hypophosphatasia patient","year":2022,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Hypophosphatasia; Induced pluripotent stem cell; Biology; Pathogenesis; Cell culture; In vitro; Compound heterozygosity; Disease; Gene; Mutation; Bioinformatics; Genetics; Alkaline phosphatase; Enzyme; Immunology; Embryonic stem cell; Internal medicine; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001434737,0.0002220307,0.000502123,0.0003907343,0.0007334913,0.00002665322,0.0003870774,0.00007070167,0.001927478],"category_scores_gemma":[0.00005637605,0.0002071806,0.000151384,0.0009607802,0.0001932281,0.00008464085,0.001288265,0.001070992,0.000137366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004690176,"about_ca_system_score_gemma":0.000844795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004286875,"about_ca_topic_score_gemma":0.00007458525,"domain_scores_codex":[0.9944335,0.0005115057,0.0006075795,0.0006460244,0.003017025,0.0007843295],"domain_scores_gemma":[0.9976074,0.000340076,0.0001519101,0.0009108783,0.000547886,0.0004418126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001224746,0.002231683,0.004248616,0.0005065119,0.0002342408,0.0005600117,0.005658442,0.0003001544,0.5117286,0.0002655744,0.4348274,0.03821399],"study_design_scores_gemma":[0.004540276,0.00524501,0.001238031,0.00006860213,0.00007695545,0.000008015732,0.007034321,0.001565575,0.9107864,0.0005044456,0.06860209,0.0003303099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9482524,0.04440488,0.00003310411,0.0009392941,0.00015907,0.001519698,0.0004885385,0.000045544,0.004157501],"genre_scores_gemma":[0.9867067,0.001186104,0.0005125097,0.00007656665,0.0004106016,0.000208041,0.0008639998,0.00006105144,0.009974396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3990577,"threshold_uncertainty_score":0.9989849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2353348842658879,"score_gpt":0.4083293265251982,"score_spread":0.1729944422593103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}