{"id":"W4290786383","doi":"10.1016/j.scr.2022.102891","title":"Generation of new human iPSC cell line (UOMi008-A) from a Hypophosphatasia patient","year":2022,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Hypophosphatasia; Induced pluripotent stem cell; Biology; Pathogenesis; Cell culture; In vitro; Compound heterozygosity; Disease; Gene; Mutation; Bioinformatics; Genetics; Alkaline phosphatase; Enzyme; Immunology; Embryonic stem cell; Internal medicine; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002291448,0.0002091866,0.0003338298,0.0003681712,0.000276566,0.0003814828,0.0002519308,0.0004345951,0.003621858],"category_scores_gemma":[0.0002947848,0.0001197728,0.0002807442,0.0002956446,0.0001375116,0.0001560182,0.0002439217,0.0006633599,0.001039025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001471258,"about_ca_system_score_gemma":0.0002842731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007013161,"about_ca_topic_score_gemma":0.0008066358,"domain_scores_codex":[0.999871,0.00001149624,0.00002614393,0.00003042035,0.00004264016,0.00001830279],"domain_scores_gemma":[0.9999098,0.00002156311,0.000008736662,0.00001724336,0.00002089064,0.00002183219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002766062,0.0001402969,0.002123739,0.0001445618,0.00002026791,0.002642774,0.0002699104,0.0002863408,0.9724769,0.001410965,0.002427644,0.01777992],"study_design_scores_gemma":[0.0002148539,0.001131868,0.01728943,0.0001010498,0.0001481355,0.01991275,0.0002532216,0.004202831,0.8683884,0.0006392998,0.08766495,0.00005325276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9344325,0.002733291,0.03063883,0.0006304944,0.0004285365,0.001119866,0.01032672,0.000617977,0.01907177],"genre_scores_gemma":[0.9030304,0.003050305,0.05064179,0.0005484961,0.00008977271,0.001323884,0.02187072,0.0001429772,0.01930172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003621858,"threshold_uncertainty_score":0.01211631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2353348842658879,"score_gpt":0.4083293265251982,"score_spread":0.1729944422593103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}