{"id":"W4290786630","doi":"10.3389/fimmu.2022.897912","title":"Polygenic Innate Immunity Score to Predict the Risk of Cytomegalovirus Infection in CMV D+/R- Transplant Recipients. A Prospective Multicenter Cohort Study","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Agencia Estatal de Investigación; Instituto de Salud Carlos III; Universidad de Córdoba; Universitat de Barcelona; Instituto de Investigación Marqués de Valdecilla; Universidad de Cantabria; European Regional Development Fund; Universidad de Sevilla","keywords":"Medicine; Internal medicine; Immunology; Transplantation; Valganciclovir; Single-nucleotide polymorphism; Gastroenterology; Human cytomegalovirus; Virus; Biology; Ganciclovir; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009043593,0.0004321678,0.0002929511,0.0004524851,0.0003202442,0.000486226,0.0002404248,0.0003844112,0.001240224],"category_scores_gemma":[0.001398999,0.0002371346,0.0005694594,0.0003352683,0.0001825115,0.0002292683,0.0003661866,0.0004638167,0.0002071852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000115472,"about_ca_system_score_gemma":0.0001463378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009632297,"about_ca_topic_score_gemma":0.0009604096,"domain_scores_codex":[0.9996191,0.0001475682,0.00003851115,0.0001000119,0.00004704233,0.00004768749],"domain_scores_gemma":[0.9989828,0.0001775551,0.0003965496,0.0001272647,0.00006936004,0.0002464934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002763252,0.00002378559,0.9982842,0.000002627741,0.00007214933,0.00004476915,0.00001666338,0.00004217646,0.0006390586,0.000006215068,0.00002656363,0.0005655227],"study_design_scores_gemma":[0.0000152204,0.000280858,0.9985863,0.000002197987,0.00004923585,0.0003360401,0.00003640336,0.0005022195,0.000111446,0.00001496117,0.00006185544,0.000003196466],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999676,0.00006632112,0.00009273359,0.00001096968,0.000003217488,0.000003458161,0.00007219248,0.000001867984,0.00007325484],"genre_scores_gemma":[0.9997085,0.0000153436,0.00008416453,0.000007851602,0.000004336116,0.00000293365,0.0001127223,0.000001046792,0.00006321976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001240224,"threshold_uncertainty_score":0.004782796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01356059603695541,"score_gpt":0.2754596019539717,"score_spread":0.2618990059170163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}