{"id":"W4290803778","doi":"10.1038/s41467-022-32183-6","title":"The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"U.S. National Library of Medicine; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Medical Research Council; Norwegian Institute of Public Health; National Institutes of Health; St. Olavs Hospital Universitetssykehuset i Trondheim; National Alzheimer's Coordinating Center; Norges Forskningsråd; Vanderbilt University; Faculty of Medicine and Health, University of Sydney; Institut National de la Santé et de la Recherche Médicale; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Economic and Social Research Council; Broad Institute; Case Western Reserve University; Stiftelsen Kristian Gerhard Jebsen; Norges Teknisk-Naturvitenskapelige Universitet; Helse Midt-Norge; University of Bristol; Agence Nationale de la Recherche; Wellcome Trust; University of Pennsylvania; University of Miami; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; University of Toronto","keywords":"Mendelian randomization; Phenome; Disease; Biobank; Apolipoprotein E; Pleiotropy; Risk factor; Alzheimer's disease; Dementia; Medicine; Bioinformatics; Biology; Genetics; Internal medicine; Gene; Phenotype; Genotype; Genetic variants","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03295276,0.0006145525,0.001181559,0.001018224,0.0005034076,0.001076178,0.0009939469,0.001158572,0.001967699],"category_scores_gemma":[0.07218796,0.0003879427,0.001684646,0.001449512,0.001801013,0.0009950997,0.001221668,0.0008462536,0.0001734743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002523087,"about_ca_system_score_gemma":0.0004493321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001510806,"about_ca_topic_score_gemma":0.001096411,"domain_scores_codex":[0.9530292,0.03946203,0.001353738,0.003591743,0.00219509,0.0003681636],"domain_scores_gemma":[0.9100354,0.06681285,0.007868806,0.01383267,0.0009318279,0.000518446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02573222,0.0004119023,0.7736849,0.001365655,0.03174123,0.003244943,0.001566907,0.007248852,0.007584827,0.02388936,0.003235512,0.1202937],"study_design_scores_gemma":[0.00605104,0.003981506,0.7902607,0.0004773143,0.02140455,0.005717386,0.0005187588,0.03657223,0.003609511,0.1196767,0.01150481,0.0002254917],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9052665,0.01057294,0.07643995,0.00246687,0.0003015325,0.0002920204,0.0009555611,0.0001979011,0.003506668],"genre_scores_gemma":[0.9899085,0.001101609,0.007920668,0.0004133269,0.0001066551,0.00009104984,0.0002837488,0.00002700288,0.0001475071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03295276,"threshold_uncertainty_score":0.1742729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03445149853695682,"score_gpt":0.318012374383264,"score_spread":0.2835608758463072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}