{"id":"W4290830430","doi":"10.1136/jnnp-2022-abn2.180","title":"136 NOVA primary results randomised controlled study of natalizumab Q6W versus continued Q4W treatment for MS","year":2022,"lang":"en","type":"article","venue":"Journal of Neurology Neurosurgery & Psychiatry","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; NeuroRx Research (Canada)","funders":"","keywords":"Natalizumab; Medicine; Clinical endpoint; Dosing; Internal medicine; Pediatrics; Randomized controlled trial; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004114503,0.001694761,0.004561328,0.0006933599,0.0006317466,0.001933382,0.001075627,0.001839859,0.02072475],"category_scores_gemma":[0.004539496,0.0008574827,0.004101246,0.0004491673,0.001268898,0.0009244085,0.0007216887,0.002494259,0.00232789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001178332,"about_ca_system_score_gemma":0.001664726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001367687,"about_ca_topic_score_gemma":0.003358629,"domain_scores_codex":[0.9966303,0.002018521,0.0003318041,0.0004761049,0.0002865933,0.0002567754],"domain_scores_gemma":[0.9975527,0.0007409396,0.000694457,0.0002165052,0.0002543768,0.0005410428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9885138,0.002270636,0.0002204998,0.0008564558,0.001317813,0.00001938475,0.00001578224,0.00009397606,0.001082003,0.00009539236,0.0006417831,0.004872525],"study_design_scores_gemma":[0.9697843,0.02688075,0.001147345,0.00006600707,0.0008180709,0.0000165933,0.000007424534,0.0001428428,0.0001408589,0.000116733,0.0008671672,0.00001197957],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9094609,0.02440125,0.002707792,0.002117145,0.003862509,0.03017096,0.01237325,0.0003433981,0.01456277],"genre_scores_gemma":[0.9471195,0.005595862,0.004048676,0.002216995,0.001458918,0.02149588,0.004755197,0.00006779377,0.01324109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02072475,"threshold_uncertainty_score":0.06933117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03252736182210775,"score_gpt":0.3036362181753625,"score_spread":0.2711088563532547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}